Welchol

Welchol is a bile acid sequestrant. Welchol is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in the body. Removing these bile acids helps to lower blood cholesterol.

Medicinal name:
  • Colesevelam hydrochloride 625 MG Oral Tablet [Welchol]

Welchol - Pharmacology:

Welchol is a non-absorbed, lipid-lowering polymer that binds bile acids in the intestine, impeding their reabsorption. As the bile acid pool becomes depleted, the hepatic enzyme, cholesterol 7-(alpha)-hydroxylase, is upregulated, which increases the conversion of cholesterol to bile acids. This causes an increased demand for cholesterol in the liver cells, resulting in the dual effect of increasing transcription and activity of the cholesterol biosynthetic enzyme, hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase, and increasing the number of hepatic low-density lipoprotein (LDL) receptors. These compensatory effects result in increased clearance of LDL cholesterol (LDL-C) from the blood, resulting in decreased serum LDL-C levels. Serum triglyceride levels may increase or remain unchanged. The end result is increased clearance of LDL-cholesterol from the blood with decreased serum LDL-cholesterol.

Welchol mini report

Welchol NDA
NDA - A product marketed under an approved New Drug Application
Welchol FOR SUSPENSION
FOR SUSPENSION
Welchol TABLET, FILM COATED
TABLET, FILM COATED
Welchol HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Welchol global name
colesevelam hydrochloride
Start - Stop data
START DATA:
2010-Jan-01
Start - Stop data
STOP DATA
not occurred

Welchol for patients

WelChol® may be taken once per day with a meal, or taken twice per day in divided doses with meals. Patients should be directed to take WelChol® with a liquid and a meal, and adhere to their NCEP-recommended diet. Patients should tell their physicians if they are pregnant, are intending to become pregnant, or are breastfeeding.

What is Welchol used for?

Welchol is used alone or with another drug to lower high levels of low-density lipoprotein (LDL) in the blood when response to diet and non-drug therapy is inadequate. Diet and exercise are very important factors to help control cholesterol.

Who should not take Welchol?

Do not take Welchol if you have a blockage of your intestinal tract

What does my doctor or health care provider need to know?

Tell your doctor or health care provider if you have:

  • difficulty in swallowing, severe intestinal problems, or have had major abdominal surgery
  • fat soluble vitamin deficiencies
  • high triglyceride levels (> 300mg/dL)

What are some possible side effects of Welchol? (This is NOT a complete list of side effects reported with Welchol. Your health care provider can discuss with you a more complete list of side effects.)

  • Indigestion
  • Constipation
  • Gas

For more detailed information about Welchol, ask your health care provider.

Welchol Interactions

WelChol® has been studied in several human drug interaction studies in which it was administered with a meal and the test drug. WelChol® was found to have no significant effect on the bioavailability of digoxin, lovastatin, metoprolol, quinidine, valproic acid, and warfarin. WelChol® decreased the Cmax and AUC of sustained-release verapamil (Calan SR®) by approximately 31% and 11%, respectively. Since there is a high degree of variability in the bioavailability of verapamil, the clinical significance of this finding is unclear. In clinical studies, coadministration of WelChol® with atorvastatin, lovastatin, or simvastatin did not interfere with the lipid-lowering activity of the HMG-CoA reductase inhibitor. Other drugs have not been studied. When administering other drugs for which alterations in blood levels could have a clinically significant effect on safety or efficacy, physicians should consider monitoring drug levels or effects.

Welchol Contraindications

WelChol® is contraindicated in individuals with bowel obstruction and in individuals who have shown hypersensitivity to any of the components of WelChol®.

Manufacturers name:

  • Physicians Total Care, Inc
  • Rebel Distributors Corp
  • Daiichi Sankyo, inc
  • Carilion Materials Management

Generic name, Overdose, Half Life Welchol, Food Interactions, Chemical, etc..

Welchol see also FDA report

Brand Names containing Colesevelam