Zantac

A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers. .
[PubChem].

Medicinal name:
  • Ranitidine 150 MG Oral Tablet [Zantac]
  • Ranitidine 300 MG Oral Tablet [Zantac]
  • Ranitidine 75 MG Oral Tablet [Zantac]

Zantac - Pharmacology:

The H2 antagonists are competitive inhibitors of histamine at the parietal cell H2 receptor. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: histamine released by ECL cells in the stomach is blocked from binding on parietal cell H2 receptors which stimulate acid secretion, and other substances that promote acid secretion (such as gastrin and acetylcholine) have a reduced effect on parietal cells when the H2 receptors are blocked.

Zantac mini report

Zantac NDA
NDA - A product marketed under an approved New Drug Application
Zantac INTRAMUSCULAR; INTRAVENOUS
INTRAMUSCULAR; INTRAVENOUS
Zantac ORAL
ORAL
Zantac INJECTION, SOLUTION
INJECTION, SOLUTION
Zantac TABLET, COATED
TABLET, COATED
Zantac TABLET, FILM COATED
TABLET, FILM COATED
Zantac HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Zantac HUMAN OTC DRUG
HUMAN OTC DRUG
Zantac global name
ranitidine hydrochloride
Zantac global name
ranitidine
Start - Stop data
START DATA:
1989-Oct-01
Start - Stop data
STOP DATA
not occurred

Zantac for patients

Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved on the tongue.

Zantac Interactions

Coadministration of TRITEC with clarithromycin resulted in increased plasma ranitidine concentrations (57%), increased plasma bismuth trough concentrations (48%), and increased 14- hydroxy- clarithromycin plasma concentrations (31%). Coadministration with aspirin results in a slight decrease in the rate of salicylate absorption that is clinically unimportant. Coadministration with a high dose of antacid (170 mEq) results in a 28% decrease in plasma concentrations of ranitidine and may decrease plasma concentrations of bismuth from TRITEC. These effects are clinically insignificant.

For information on drug interactions associated with ranitidine, refer to the ZANTAC ® package insert.

Zantac Contraindications

TRITEC is contraindicated in patients known to have hypersensitivity to ranitidine bismuth citrate or any of its ingredients.

For information on clarithromycin contraindications, see clarithromycin package insert.

Manufacturers name:

  • Lil Drug Store Products, Inc
  • GlaxoSmithKline LLC
  • Carilion Materials Management
  • Boehringer Ingelheim Pharmaceuticals Inc

Zantac tags categories:

Generic name, Overdose, Half Life Zantac, Food Interactions, Chemical, etc..

Zantac see also FDA report Saw Palmetto