Zoloft Indication:

For the treatment of posttraumatic stress disorder, depression, obsessive-compulsive disorder and panic disorder

Zoloft Mechanism Of Action:

It is believed that sertraline inhibits reuptake of serotonin at the neuronal membrane. SSRIs have less sedative, anticholinergic, and cardiovascular effects than the tricyclic antidepressant drugs because of decreased binding to histamine, acetylcholine, and norepinephrine receptors.

Zoloft Drug Interactions:

Not Available

Zoloft Food Interactions:

Avoid alcohol.
Take with food.
Avoid taking with grapefruit juice.
Avoid St.John's Wort.

Zoloft Generic Name:

Synonyms:

  • Sertralina [Spanish]
  • Sertraline Hydrochloride
  • Sertralinum [Latin]
  • Sultamicillin Tosylate

Drug Type:

Small Molecule; Approved

Absorption:

The effects of food on the bioavailability of the sertraline tablet and oral concentrate were studied in subjects administered a single dose with and without food. For the tablet, AUC was slightly increased when drug was administered with food but the Cmax was 25% greater, while the time to reach peak plasma concentration (Tmax) decreased from 8 hours post-dosing to 5.5 hours. For the oral concentrate, Tmax was slightly prolonged from 5.9 hours to 7.0 hours with food.

Toxicity (Overdose):

Symptoms of toxicity include alopecia, decreased libido, diarrhea, ejaculation disorder, fatigue, insomnia, somnolence and serotonin syndrome.

Protein Binding:

98%

Biotransformation:

Hepatic

Half Life:

26 hours

Dosage Forms of Zoloft:

Capsule Oral

Chemical IUPAC Name:

(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine

Organisms Affected:

Humans and other mammals

Zoloft to general, pharmacology

General, pharmacology..
Antidepressants