Zyban Indication:

For the treatment of depression and as aid to smoking cessation.

Zyban Mechanism Of Action:

Zyban selectively inhibits the neuronal reuptake of dopamine, norepinephrine, and serotonin; actions on dopaminergic systems are more significant than imipramine or amitriptyline whereas the blockade of norepinephrine and serotonin reuptake at the neuronal membrane is weaker for bupropion than for tricyclic antidepressants. The increase in norepinephrine may attenuate nicotine withdrawal symptoms and the increase in dopamine at neuronal sites may reduce nicotine cravings and the urge to smoke. Zyban exhibits moderate anticholinergic effects.

Zyban Drug Interactions:

Carbamazepine Carbamazepine decreases the effect of bupropion
Cyclosporine Decreases the effect of cyclosporine
Isocarboxazid Possible severe adverse reaction with this combination
Phenelzine Possible severe adverse reaction with this combination
Rasagiline Possible severe adverse reaction with this combination
Rifabutin Rifampin reduces bupropion levels
Rifampin Rifampin reduces bupropion levels
Ritonavir Ritonavir increases the effect and toxicity of bupropion
Thioridazine Inceases the effect and toxicity of thioridazine
Tranylcypromine Possible severe adverse reaction with this combination

Zyban Food Interactions:

Take without regard to meals.
Avoid alcohol.
Avoid St.John's Wort.

Zyban Generic Name:

Synonyms:

  • Bupropion Hcl
  • Amfebutamone

Drug Type:

Small Molecule; Approved

Absorption:

For sustained release, peak plasma concentrations are achieved within 3 hours.

Toxicity (Overdose):

Symptoms of overdose include seizures, hallucinations, loss of consciousness, tachycardia, and cardiac arrest.

Protein Binding:

84 %

Biotransformation:

Reduction of the carbonyl groupand/or hydroxylation of the tert-butyl group of bupropion.

Half Life:

24 hours

Dosage Forms of Zyban:

Tablet, extended release Oral

Chemical IUPAC Name:

2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one

Organisms Affected:

Humans and other mammals

Zyban to general, pharmacology

General, pharmacology..