A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex.

ACTH - Pharmacology:

ACTH combines with a specific receptor in the adrenal cell plasma membrane and, in patients with normal adrenocortical function, stimulates the initial reaction involved in the synthesis of adrenal steroids (including cortisol, cortisone, weak androgenic substances, and a limited quantity of aldosterone) from cholesterol by increasing the quantity of the substrate within the mitochondria. ACTH does not significantly increase plasma cortisol concentration in patients with primary or secondary adrenocortical insufficiency.

ACTH Interactions

Corticotropin may accentuate the electrolyte loss associated with diuretic therapy.

ACTH Contraindications

The only contraindication to Cortrosyn® is a history of a previous adverse reaction to it.

ACTH tags categories:

Generic name, Overdose, Half Life ACTH, Food Interactions, Chemical, etc..

ACTH see also

Brand Names containing Cosyntropin