A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)

ACTINOMYCIN D - Pharmacology:

Good evidence exists that this drug bind strongly, but reversibly, to DNA, interfering with synthesis of RNA and, consequently, with protein synthesis.

ACTINOMYCIN D for patients

ACTINOMYCIN D is a type of antibiotic that is only used in cancer
chemotherapy. It slows or stops the growth of cancer cells in your
body. The length of treatment depends on the types of drugs you are
taking, how well your body responds to them, and the type of cancer
you have. tell your doctor and pharmacist if you are allergic to
dactinomycin or any other drugs. tell your doctor and pharmacist
what prescription and nonprescription medications you are taking,
especially aspirin and vitamins. tell your doctor if you have or
have ever had liver disease, ulcers, or gastrointestinal disease.
you should know that dactinomycin may interfere with the normal
menstrual cycle (period) in women and may stop sperm production
in men. However, you should not assume that you cannot get pregnant
or that you cannot get someone else pregnant. Women who are pregnant
or breast-feeding should tell their doctors before they begin taking
this drug. You should not plan to have children while receiving
chemotherapy or for a while after treatments. (Talk to your doctor
for further details.) Use a reliable method of birth control to
prevent pregnancy. ACTINOMYCIN D may harm the fetus. do not have any
vaccinations (e.g., measles or flu shots) without talking to your

ACTINOMYCIN D Interactions

Drug/LaboratoryTest Interactions

ACTINOMYCIN D may interfere with bioassay procedures for the determination of antibacterial drug levels.

ACTINOMYCIN D Contraindications

Hypersensitivity to any component of this product.

COSMEGEN should not be given at or about the time of infection with chickenpox or herpes zoster because of the risk of severe generalized disease which may result in death.

ACTINOMYCIN D tags categories:

Generic name, Overdose, Half Life ACTINOMYCIN D, Food Interactions, Chemical, etc..


Brand Names containing Dactinomycin

Chemical structure:
N N N N O O O O O O O O O N N N N N O O O O O O O N N N H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H C62H86N12O16 2D chemical structure C62H86N12O16 SVG | 2D structure chemical names, chemical properties, classification C62H86N12O16