Abilify

Abilify is an atypical antipsychotic medication used for the treatment of schizophrenia. It has also recently received FDA approval for the treatment of acute manic and mixed episodes associated with bipolar disorder. Abilify appears to mediate its antipsychotic effects primarily by partial agonism at the D2 receptor. In addition to partial agonist activity at the D2 receptor, aripiprazole is also a partial agonist at the 5-HT1A receptor, and like the other atypical antipsychotics, aripiprazole displays an antagonist profile at the 5-HT2A receptor. Abilify has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.

Medicinal name:
  • Aripiprazole 5 MG Oral Tablet [Abilify]
  • Aripiprazole 2 MG Oral Tablet [Abilify]
  • Aripiprazole 15 MG Oral Tablet [Abilify]
  • Aripiprazole 10 MG Oral Tablet [Abilify]
  • Aripiprazole 20 MG Oral Tablet [Abilify]
  • Aripiprazole 30 MG Oral Tablet [Abilify]
  • Aripiprazole 10 MG Disintegrating Oral Tablet [Abilify]
  • Aripiprazole 15 MG Disintegrating Oral Tablet [Abilify]

Abilify - Pharmacology:

Abilify exhibits high affinity for dopamine D2 and D3, serotonin 5-HT1A and 5- HT2A receptors, moderate affinity for dopamine D4, serotonin 5-HT2C and 5-HT7, alpha1-adrenergic and histamine H1 receptors and moderate affinity for the serotonin reuptake pump. Abilify has no appreciable affinity for cholinergic muscarinic receptors. Abilify functions as a partial agonist at the dopamine D2 and the serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A receptor.

Abilify mini report

Abilify NDA
NDA - A product marketed under an approved New Drug Application
Abilify INTRAMUSCULAR
INTRAMUSCULAR
Abilify ORAL
ORAL
Abilify INJECTION, SOLUTION
INJECTION, SOLUTION
Abilify SOLUTION
SOLUTION
Abilify TABLET
TABLET
Abilify TABLET, ORALLY DISINTEGRATING
TABLET, ORALLY DISINTEGRATING
Abilify HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Abilify global name
ARIPIPRAZOLE
Abilify global name
Aripiprazole
Start - Stop data
START DATA:
2006-Sep-20
Start - Stop data
STOP DATA
not occurred

Abilify for patients

Physicians are advised to discuss the following issues with patients for whom they prescribe ABILIFY:

Interference with Cognitive and Motor Performance

Because aripiprazole may have the potential to impair judgment, thinking, or motor skills, patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that aripiprazole therapy does not affect them adversely.

Pregnancy

Patients should be advised to notify their physician if they become pregnant or intend to become pregnant during therapy with ABILIFY.

Nursing

Patients should be advised not to breast-feed an infant if they are taking ABILIFY.

Concomitant Medication

Patients should be advised to inform their physicians if they are taking, or plan to take, any prescription or over-the-counter drugs, since there is a potential for interactions.

Alcohol

Patients should be advised to avoid alcohol while taking ABILIFY.

Heat Exposure and Dehydration

Patients should be advised regarding appropriate care in avoiding overheating and dehydration.

Sugar Content

Patients should be advised that each mL of ABILIFY oral solution contains 400 mg of sucrose and 200 mg of fructose.

Abilify Interactions

Drug-Drug Interactions

Given the primary CNS effects of aripiprazole, caution should be used when ABILIFY is taken in combination with other centrally acting drugs and alcohol. Due to its α1- adrenergic receptor antagonism, aripiprazole has the potential to enhance the effect of certain antihypertensive agents.

Potential for Other Drugs to Affect ABILIFY

Abilify is not a substrate of CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, or CYP2E1 enzymes. Abilify also does not undergo direct glucuronidation. This suggests that an interaction of aripiprazole with inhibitors or inducers of these enzymes, or other factors, like smoking, is unlikely.

Both CYP3A4 and CYP2D6 are responsible for aripiprazole metabolism. Agents that induce CYP3A4 (eg, carbamazepine) could cause an increase in aripiprazole clearance and lower blood levels. Inhibitors of CYP3A4 (eg, ketoconazole) or CYP2D6 (eg, quinidine, fluoxetine, or paroxetine) can inhibit aripiprazole elimination and cause increased blood levels.

Ketoconazole: Coadministration of ketoconazole (200 mg/day for 14 days) with a 15-mg single dose of aripiprazole increased the AUC of aripiprazole and its active metabolite by 63% and 77%, respectively. The effect of a higher ketoconazole dose (400 mg/day) has not been studied. When concomitant administration of ketoconazole with aripiprazole occurs, aripiprazole dose should be reduced to one-half of its normal dose. Other strong inhibitors of CYP3A4 (itraconazole) would be expected to have similar effects and need similar dose reductions; weaker inhibitors (erythromycin, grapefruit juice) have not been studied. When the CYP3A4 inhibitor is withdrawn from the combination therapy, aripiprazole dose should then be increased.

Quinidine: Coadministration of a 10-mg single dose of aripiprazole with quinidine (166 mg/day for 13 days), a potent inhibitor of CYP2D6, increased the AUC of aripiprazole by 112% but decreased the AUC of its active metabolite, dehydroaripiprazole, by 35%. Abilify dose should be reduced to one-half of its normal dose when concomitant administration of quinidine with aripiprazole occurs. Other significant inhibitors of CYP2D6, such as fluoxetine or paroxetine, would be expected to have similar effects and, therefore, should be accompanied by similar dose reductions. When the CYP2D6 inhibitor is withdrawn from the combination therapy, aripiprazole dose should then be increased.

Carbamazepine: Coadministration of carbamazepine (200 mg BID), a potent CYP3A4 inducer, with aripiprazole (30 mg QD) resulted in an approximate 70% decrease in Cmax and AUC values of both aripiprazole and its active metabolite, dehydro-aripiprazole. When carbamazepine is added to aripiprazole therapy, aripiprazole dose should be doubled. Additional dose increases should be based on clinical evaluation. When carbamazepine is withdrawn from the combination therapy, aripiprazole dose should then be reduced.

No clinically significant effect of famotidine, valproate, or lithium was seen on the pharmacokinetics of aripiprazole (see CLINICAL PHARMACOLOGY: Drug- Drug Interactions).

Potential for ABILIFY to Affect Other Drugs

Abilify is unlikely to cause clinically important pharmacokinetic interactions with drugs metabolized by cytochrome P450 enzymes. In in vivo studies, 10- to 30-mg/day doses of aripiprazole had no significant effect on metabolism by CYP2D6 (dextromethorphan), CYP2C9 (warfarin), CYP2C19 (omeprazole, warfarin), and CYP3A4 (dextromethorphan) substrates. Additionally, aripiprazole and dehydroaripiprazole did not show potential for altering CYP1A2-mediated metabolism in vitro.

Alcohol: There was no significant difference between aripiprazole coadministered with ethanol and placebo coadministered with ethanol on performance of gross motor skills or stimulus response in healthy subjects. As with most psychoactive medications, patients should be advised to avoid alcohol while taking ABILIFY.

 

Abilify Contraindications

ABILIFY is contraindicated in patients with a known hypersensitivity to the product.

Manufacturers name:

  • Bryant Ranch Prepack
  • Carilion Materials Management
  • Rebel Distributors Corp
  • Otsuka America Pharmaceutical, Inc
  • REMEDYREPACK INC
  • TYA Pharmaceuticals
  • Aphena Pharma Solutions - Tennessee, LLC
  • Cardinal Health
  • Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC
  • Lake Erie Medical DBA Quality Care Products LLC
  • Lake Erie Medical Surgical & Supply DBA Quality Care Products LLC
  • STAT RX USA LLC
  • Physicians Total Care, Inc
  • PD-Rx Pharmaceuticals, Inc
  • HJ Harkins Company, Inc

Generic name, Overdose, Half Life Abilify, Food Interactions, Chemical, etc..

Abilify see also Hibiscus flowers

Brand Names containing Aripiprazole