For diuretics and digitalis in congestive heart failure as adjunctive therapy and for use in prophylaxis in post MI.
Altace Mechanism Of Action:
Altaceat, the active metabolite, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and an increase in plasma renin. Altaceat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin.
Altace Drug Interactions:
Drospirenone Increased risk of hyperkaliemia
Amiloride Increased risk of hyperkaliemia
Potassium Increased risk of hyperkaliemia
Lithium The ACE inhibitor increases serum levels of lithium
Spironolactone Increased risk of hyperkaliemia
Triamterene Increased risk of hyperkaliemia
Tizanidine Tizanidine increases the risk of hypotension with the ACE inhibitor
Chemical IUPAC Name: