Asmanex Twisthaler

Asmanex Twisthaler is a medium-potency synthetic corticosteroid with antiinflammatory, antipruritic, and vasoconstrictive properties. Studies in asthmatic patients have demonstrated that mometasone provides a favorable ratio of topical to systemic activity due to its primary local effect along with the extensive hepatic metabolism and the lack of active metabolites. Though effective for the treatment of asthma, glucocorticoids do not affect asthma symptoms immediately. Maximum improvement in symptoms following inhaled administration of mometasone furoate may not be achieved for 1 to 2 weeks or longer after starting treatment. he antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

Asmanex Twisthaler - Pharmacology:

Unbound corticosteroids cross cell membranes and bind with high affinity to specific cytoplasmic receptors. Inflammation is decreased by diminishing the release of leukocytic acid hydrolases, prevention of macrophage accumulation at inflamed sites, interference with leukocyte adhesion to the capillary wall, reduction of capillary membrane permeability, reduction of complement components, inhibition of histamine and kinin release, and interference with the formation of scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Asmanex Twisthaler furoate has been shown in vitro to exhibit a binding affinity for the human glucocorticoid receptor which is approximately 12 times that of dexamethasone, 7 times that of triamcinolone acetonide, 5 times that of budesonide, and 1.5 times that of fluticasone.

Asmanex Twisthaler for patients

PATIENTS INSTRUCTIONS FOR USE ASMANEX®TWISTHALER®220 mcg (mometasone furoate inhalation powder)


Please read this leaflet carefully before taking ASMANEX® TWISTHALER®. This leaflet does not contain the complete information about this medication. If you have any questions about ASMANEX® TWISTHALER®, ask your healthcare provider or pharmacist.


• Your healthcare provider has prescribed ASMANEX® TWISTHALER®. It contains a medication called mometasone furoate, which is a synthetic corticosteroid. This medication is used as maintenance treatment that helps prevent and control asthma symptoms.

• ASMANEX® TWISTHALER® is not a bronchodilator. You should not use ASMANEX® TWISTHALER® when you are having sudden symptoms of shortness of breath. Use an inhaled short-acting bronchodilator such as albuterol to relieve sudden symptoms of shortness of breath.

• Your healthcare provider may prescribe bronchodilators such as albuterol for emergency relief if an acute asthma attack occurs.

• The inhaler delivers your medication as a very fine powder that you may (b)(4) mell or feel. Whether or not you are able to sense of a dose, not take extra ess your healthcare provider has told you to.

• Use the inhaler regularly and at the same time each day as prescribed by your healthcare provider. Maximum benefit may not be achieved for 1 to 2 weeks or longer. If your symptoms do not improve in that time frame or if your condition worsens, contact your healthcare provider.

Do not use the inhaler if you notice that it is not working correctly. Take it to your healthcare provider or pharmacist.


Remove the ASMANEX® TWISTHALER® from its foil pouch and write the date on the cap label. Its important to throw away the inhaler 45 days after this date or when the dose counter reads "00", whichever comes first.

Step 1. Open inhaler

Hold the inhaler straight up with the pink portion (the base) on the bottom. It is important that you remove the cap of the TWISTHALER® while it is in this upright position to make sure that you get the right amount of medicine with each dose.

Holding the pink base, twist the cap in a counter- clockwise direction to remove it. As you lift off the cap, the dose counter on the base will count down by one. (If you began with the dose counter reading "30," this action will cause it to now read "29.") This action loads the device with the medicine that you are now ready to inhale.

IT IS IMPORTANT TO NOTE that the indented arrow (located on the white portion of the TWISTHALER®, directly above the pink base) is pointing to the dose counter.

Step 2. Inhale dose

Exhale fully. Then bring the TWISTHALER® up to your mouth with the mouthpiece facing toward you. Place it in your mouth, holding it in a horizontal position. Firmly closing your lips around the mouthpiece, take in a fast, deep breath. Since the medication is a very fine powder, you may not be able to feel or taste it after inhalation.

Remove the TWISTHALER® from your mouth and hold your breath for about 10 seconds, or as long as you comfortably can.


After you take your medicine, it is important that you wipe the mouthpiece dry, if necessary, and immediately replace the cap, firmly closing the TWISTHALER®.

This is the only way to be sure that your next dose is properly loaded. Be sure that the arrow is in line with the dose-counter window. The cap needs to be put back on and turned in a clockwise direction, as you gently press down. Youll hear a distinctive "click" to let you know that the cap is fully closed.


Rinse your mouth after using.


Keep your inhaler clean and dry at all times. If the device needs cleaning, gently wipe the mouthpiece with a dry cloth or tissue as needed. Do not wash the inhaler. Avoid contact with any liquids.

Store in a dry place at 25°C (77F°); excursions permitted to 15-30°C (59-86°F)

Keep your inhaler out of the reach of young children.


The inhaler has a dose indicator window on the pink base. It is a dose counter which displays the number of doses remaining. When the unit reads 01, this indicates the last remaining dose. After dose 01, the counter will read 00, and the cap will lock. The unit must then be discarded.

Asmanex Twisthaler Interactions

In clinical studies, the concurrent administration of the ASMANEX® TWISTHALER® inhaler and other drugs commonly used in the treatment of asthma was not associated with any unusual adverse events. However, ketoconazole, a potent inhibitor of cytochrome P450 3A4, may increase plasma levels of mometasone furoate during concomitant dosing.

Asmanex Twisthaler Contraindications

ASMANEX® TWISTHALER® therapy is contraindicated in the primary treatment of status asthmaticus or other acute episodes of asthma where intensive measures are required. Hypersensitivity to any of the ingredients of this preparation contraindicates its use.

Asmanex Twisthaler tags categories:

Generic name, Overdose, Half Life Asmanex Twisthaler, Food Interactions, Chemical, etc..

Asmanex Twisthaler see also Anise

Brand Names containing Mometasone
Skin Care

Chemical structure:
O Cl Cl H H O O O H H H H H H H H H H H H H H H H H H H H H H H H H H C22H28Cl2O4 2D chemical structure C22H28Cl2O4 SVG | 2D structure Mometasone chemical names, chemical properties, classification C22H28Cl2O4