Benazepril HCl

Benazepril HCl, brand name Lotensin®, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.

Medicinal name:
  • Benazepril hydrochloride 5 MG Oral Tablet
  • Benazepril hydrochloride 10 MG / Hydrochlorothiazide 12.5 MG Oral Tablet
  • Benazepril hydrochloride 10 MG Oral Tablet
  • Benazepril hydrochloride 40 MG Oral Tablet
  • Benazepril hydrochloride 20 MG / Hydrochlorothiazide 25 MG Oral Tablet
  • Benazepril hydrochloride 20 MG Oral Tablet
  • Benazepril hydrochloride 20 MG / Hydrochlorothiazide 12.5 MG Oral Tablet
  • Benazepril hydrochloride 5 MG / Hydrochlorothiazide 6.25 MG Oral Tablet
  • Benazepril hydrochloride 20 MG / HCTZ 25 MG Oral Tablet
  • Benazepril hydrochloride 5 MG / HCTZ 6.25 MG Oral Tablet
  • Benazepril hydrochloride 20 MG / HCTZ 12.5 MG Oral Tablet

Benazepril HCl - Pharmacology:

Benazepril HClat, the active metabolite of Benazepril HCl, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion. Benazepril HClat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin.

Benazepril HCl mini report

Benazepril HCl ANDA
ANDA - A product marketed under an approved Abbreviated New Drug Application
Start - Stop data
Start - Stop data
not occurred

Benazepril HCl for patients


Female patients of childbearing age should be told about the consequences of second- and third-trimester exposure to ACE inhibitors, and they should also be told that these consequences do not appear to have resulted from intrauterine ACE inhibitor exposure that has been limited to the first trimester. These patients should be asked to report pregnancies to their physicians as soon as possible.


Angioedema, including laryngeal edema, can occur at any time with treatment with ACE inhibitors. Patients should be so advised and told to report immediately any signs or symptoms suggesting angioedema (swelling of face, eyes, lips, or tongue, or difficulty in breathing) and to take no more drug until they have consulted with the prescribing physician.

Symptomatic Hypotension

Patients should be cautioned that lightheadedness can occur, especially during the first days of therapy, and it should be reported to the prescribing physician. Patients should be told that if syncope occurs, Lotensin should be discontinued until the prescribing physician has been consulted.

All patients should be cautioned that inadequate fluid intake or excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure, with the same consequences of lightheadedness and possible syncope.


Patients should be told not to use potassium supplements or salt substitutes containing potassium without consulting the prescribing physician.


Patients should be told to promptly report any indication of infection (e.g., sore throat, fever), which could be a sign of neutropenia.

Benazepril HCl Interactions


Patients on diuretics, especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with Lotensin. The possibility of hypotensive effects with Lotensin can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with Lotensin. If this is not possible, the starting dose should be reduced.

Potassium Supplements and Potassium-Sparing Diuretics

Lotensin can attenuate potassium loss caused by thiazide diuretics. Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) or potassium supplements can increase the risk of hyperkalemia. Therefore, if concomitant use of such agents is indicated, they should be given with caution, and the patient’s serum potassium should be monitored frequently.

Oral Anticoagulants

Interaction studies with warfarin and acenocoumarol failed to identify any clinically important effects on the serum concentrations or clinical effects of these anticoagulants.


Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving ACE inhibitors during therapy with lithium. These drugs should be coadministered with caution, and frequent monitoring of serum lithium levels is recommended. If a diuretic is also used, the risk of lithium toxicity may be increased.


No clinically important pharmacokinetic interactions occurred when Lotensin was administered concomitantly with hydrochlorothiazide, chlorthalidone, furosemide, digoxin, propranolol, atenolol, naproxen, or cimetidine.

Lotensin has been used concomitantly with beta-adrenergic-blocking agents, calcium-channel-blocking agents, diuretics, digoxin, and hydralazine, without evidence of clinically important adverse interactions. Benazepril HCl, like other ACE inhibitors, has had less than additive effects with beta-adrenergic blockers, presumably because both drugs lower blood pressure by inhibiting parts of the renin-angiotensin system.



Benazepril HCl Contraindications

Lotensin is contraindicated in patients who are hypersensitive to this product or to any other ACE inhibitor.

Manufacturers name:

  • Rebel Distributors Corp
  • Physicians Total Care, Inc
  • Apotex Corp
  • Amneal Pharmaceuticals of New York, LLC
  • Mylan Pharmaceuticals Inc
  • St Marys Medical Park Pharmacy
  • Eon Labs, Inc
  • PD-Rx Pharmaceuticals, Inc
  • Aidarex Pharmaceuticals LLC
  • Major Pharmaceuticals
  • Preferred Pharmaceuticals, Inc
  • Ranbaxy Pharmaceuticals Inc
  • Clinical Solutions Wholesale
  • HJ Harkins Company, Inc
  • Bryant Ranch Prepack
  • Rising Pharmaceuticals, Inc
  • Solco healthcare US, LLC
  • Lake Erie Medical DBA Quality Care Products LLC
  • AvPAK
  • Unit Dose Services
  • Andrx Pharmaceuticals, Inc
  • International Labs, Inc
  • Andrx Pharmaceuticals
  • Blenheim Pharmacal, Inc
  • Trigen Laboratories, Inc
  • AvKARE, Inc
  • Teva Pharmaceuticals USA Inc
  • Upsher-Smith Laboratories, Inc
  • Mylan Institutional Inc
  • Aurobindo Pharma Limited
  • American Health Packaging
  • Cardinal Health
  • Northwind Pharmaceuticals
  • Stat Rx USA

Benazepril HCl tags categories:

Generic name, Overdose, Half Life Benazepril HCl, Food Interactions, Chemical, etc..

Benazepril HCl see also Barrenwort

Brand Names containing Benazepril
Blood Pressure

Chemical structure:
O N _ O + N O O O H H H H H H H H H H H H H H H H H H H H H H H H H H H H C24H28N2O5 2D chemical structure C24H28N2O5 SVG | 2D structure chemical names, chemical properties, classification C24H28N2O5