Calan Indication:

For the treatment of hypertension and angina.

Calan Mechanism Of Action:

Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, verapamil, like diltiazem, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries,improved oxygen delivery to the myocardial tissue, and decreased total peripheral resistance, systemic blood pressure, and afterload.

Calan Drug Interactions:

Not Available

Calan Food Interactions:

Avoid alcohol.
Take with food.
Avoid excessive quantities of coffee or tea (Caffeine).
Avoid taking with grapefruit juice.
Avoid natural licorice.

Calan Generic Name:


  • Verapamil [Usan:Ban:Inn]
  • Verapamil HCl
  • Verapamilo [Inn-Spanish]
  • Verapamilum [Inn-Latin]

Drug Type:

Small Molecule; Approved



Toxicity (Overdose):

LD50=8 mg/kg (i.v. in mice)

Protein Binding:



Not Available

Half Life:

2.8-7.4 hours

Dosage Forms of Calan:

Solution Intravenous
Liquid Intravenous
Tablet, extended release Oral
Tablet Oral
Capsule, extended release Oral

Chemical IUPAC Name:


Organisms Affected:

Humans and other mammals

Calan to general, pharmacology

General, pharmacology..
Blood Pressure