Casodex is an oral non-steroidal anti-androgen for prostate cancer. It binds to the androgen receptor.

Medicinal name:
  • Bicalutamide 50 MG Oral Tablet [Casodex]

Casodex - Pharmacology:

Casodex competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue.

Casodex mini report

Casodex NDA
NDA - A product marketed under an approved New Drug Application
Start - Stop data
Start - Stop data
not occurred

Casodex for patients

Patients should be informed that therapy with CASODEX and the LHRH analogue should be initiated concomitantly, and that they should not interrupt or stop taking these medications without consulting their physician. Treatment with CASODEX should be started at the same time as treatment with an LHRH analogue.

Casodex Interactions

In vitro studies have shown CASODEX can displace coumarin anticoagulants, such as warfarin, from their protein-binding sites. It is recommended that if CASODEX is started in patients already receiving coumarin anticoagulants, prothrombin times should be closely monitored and adjustment of the anticoagulant dose may be necessary.

Casodex Contraindications

CASODEX is contraindicated in any patient who has shown a hypersensitivity reaction to the drug or any of the tablets components.

CASODEX is not indicated in women. Further, CASODEX is contraindicated in women who are or may become pregnant. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. CASODEX may cause fetal harm when administered to pregnant women. The male offspring of rats receiving doses of 10mg/kg/day (plasma drug concentrations in rats equal to approximately 2/3 human therapeutic concentrations*) and above were observed to have reduced anogenital distance and hypospadias in reproductive toxicology studies. These pharmacological effects have been observed with other antiandrogens. No other teratogenic effects were observed in rabbits receiving doses up to 200mg/kg/day (approximately 1/3 human therapeutic concentrations*) or rats receiving doses up to 250 mg/kg/day (approximately 2 times human therapeutic concentrations*).

*Based on a maximum dose of 50 mg/day of bicalutamide for an average 70 kg patient.

Manufacturers name:

  • AstraZeneca Pharmaceuticals LP
  • Physicians Total Care, Inc

Casodex tags categories:

Generic name, Overdose, Half Life Casodex, Food Interactions, Chemical, etc..

Casodex see also FDA report Saw Palmetto

Men's Health