Crestor Indication:

For the treatment of pure hypercholesterolaemia and mxed hyperlipidaemia

Crestor Mechanism Of Action:

Crestor selectively and competitively inhibits the hepatic enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. As HMG-CoA reductase is responsible for converting HMG-CoA to mevalonate, this results in a decrease in mevalonate, a precursor of cholesterol, and a subsequent decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol.

Crestor Drug Interactions:

Not Available

Crestor Food Interactions:

Not Available

Crestor Generic Name:


  • ZD-4522

Drug Type:

Small Molecule; Approved; Investigational



Toxicity (Overdose):

Not Available

Protein Binding:



Not Available

Half Life:

19 hours

Dosage Forms of Crestor:

Tablet Oral

Chemical IUPAC Name:

(E,3R,5R)-7-[4-(4-fluorophenyl)-2-(methyl-methylsulfonylamino)-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid

Organisms Affected:

Humans and other mammals

Crestor to general, pharmacology

General, pharmacology..