Vinblastine derivative with antineoplastic activity against cancer. Major side effects are myelosuppression and neurotoxicity. DAVA is used extensively in chemotherapy protocols (antineoplastic combined chemotherapy protocols). .

DAVA - Pharmacology:

DAVA acts by causing the arrest of cells in metaphase mitosis through its interaction with tubulin. The drug is cell-cycle specific for the S phase.

DAVA for patients

The treatmewnt with DAVA can cause hair, but it is usually reversible. It may also cause loss of sensation or tingling in hands or feet, fever, chill, sore throat, constipation, black stool, bruising or bleeding.

Patients should be informed that the major acute toxicities of DAVA are related to bone marrow toxicity, specifically granulocytopenia with increased susceptibility to infection. They should be advised to report fever or chills immediately. Women of childbearing potential should be advised to avoid becoming pregnant during treatment. Patients should be advised to contact their physician if they experience increased shortness of breath, cough, or other new pulmonary symptoms, or if they experience symptoms of abdominal pain or constipation.

DAVA Interactions

DAVA can interact with the drugs of the following categories:

  • Blood dyscrasia: can cause unpredictable myelotoxicity
  • Bone marrow depressants: can cause a predictable dose-related myelotoxicity
  • Radiation therapy: may cause marrow depression
  • Neurotoxic medications: can cause neurologic toxicity
  • Phenytoin: can increase seizure activity
  • Live virus vaccines: may potentiate the replication of the vaccine virus, may increase the side effects of the vaccination, and decrease patients response to the vaccine
  • Mitomycin-C: may cause shortness of breath and bronchospasm
  • Killed virus vaccines: may decrease patients response to the vaccine

DAVA Contraindications

DAVA is contraindicated in patients who are known hypersensitive to DAVA, vinca alkaloids, or any component of the formulation.

DAVA tags categories:

Generic name, Overdose, Half Life DAVA, Food Interactions, Chemical, etc..

DAVA see also

Brand Names containing Vindesine