One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. .

Medicinal name:
  • Pyrimethamine 25 MG Oral Tablet [Daraprim]

Daraprim - Pharmacology:

Daraprim inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver.

Daraprim mini report

Daraprim NDA
NDA - A product marketed under an approved New Drug Application
Start - Stop data
Start - Stop data
not occurred

Daraprim for patients

Patients should be warned that at the first appearance of a skin rash they should stop use of Daraprim and seek medical attention immediately. Patients should also be warned that the appearance of sore throat, pallor, purpura, or glossitis may be early indications of serious disorders which require treatment with Daraprim to be stopped and medical treatment to be sought.

Women of childbearing potential who are taking Daraprim should be warned against becoming pregnant. Patients should be warned to keep DARAPRIM out of the reach of children. Patients should be advised not to exceed recommended doses. Patients should be warned that if anorexia and vomiting occur, they may be minimized by taking the drug with meals.

Concurrent administration of folinic acid is strongly recommended when used for the treatment of toxoplasmosis in all patients.

Daraprim Interactions

Daraprim may be used with sulfonamides, quinine and other antimalarials, and with other antibiotics. However, the concomitant use of other antifolic drugs or agents associated with myelosuppression including sulfon-amides or trimethoprim-sulfamethoxazole combinations, proguanil, zidovudine, or cytostatic agents (e.g., methotrex-ate) while the patient is receiving pyrimethamine, may increase the risk of bone marrow suppression. If signs of folate deficiency develop, pyrimethamine should be discontinued. Folinic acid (leucovorin) should be administered until normal hematopoiesis is restored. Mild hepatotoxicity has been reported in some patients when lorazepam and pyrimethamine were administered concomitantly.

Daraprim Contraindications

Use of DARAPRIM is contraindicated in patients with known hypersensitivity to pyrimethamine or to any component of the formulation. Use of the drug is also contraindicated in patients with documented megaloblastic anemia due to folate deficiency.

Manufacturers name:

  • Amedra Pharmaceuticals LLC

Generic name, Overdose, Half Life Daraprim, Food Interactions, Chemical, etc..

Daraprim see also FDA report

Brand Names containing Pyrimethamine

Chemical structure:
N N Cl N N H H H H H H H H H H H H H C12H13ClN4 2D chemical structure C12H13ClN4 SVG | 2D structure Pyrimethamine chemical names, chemical properties, classification C12H13ClN4