A nitroimidazole used to treat amebiasis; vaginitis; trichomonas infections; giardiasis; anaerobic bacteria; and treponemal infections. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).

Deflamon-Wirkstoff - Pharmacology:

Unionized metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. This reduced metronidazole then disrupts DNA's helical structure, inhibiting bacterial nucleic acid synthesis and resulting in bacterial cell death.

Deflamon-Wirkstoff for patients

Patients using METROGELÒ (metronidazole gel) 1% should receive the following information and instructions:

1. This medication is to be used as directed.

2. It is for external use only.

3. Avoid contact with the eyes.

4. Cleanse affected area(s) before applying METROGELÒ (metronidazole gel) 1%.

5. This medication should not be used for any other condition than that for which it is prescribed.

6. Patients should report any adverse reaction to their physician.

Deflamon-Wirkstoff Interactions

Oral metronidazole has been reported to potentiate the anticoagulant effect of coumarin and warfarin, resulting in a prolongation of prothrombin time. Drug interactions should be kept in mind when METROGELÒ (metronidazole gel), 1% is prescribed for patients who are receiving anticoagulant treatment, although they are less likely to occur with topical metronidazole administration because of low absorption.


Deflamon-Wirkstoff Contraindications

METROGELÒ (metronidazole gel), 1% is contraindicated in those patients with a history of hypersensitivity to metronidazole or to any other ingredient in this formulation.

Deflamon-Wirkstoff tags categories:

Generic name, Overdose, Half Life Deflamon-Wirkstoff, Food Interactions, Chemical, etc..

Deflamon-Wirkstoff see also


Chemical structure:
O + N O _ N N O H H H H H H H H H C6H9N3O3 2D chemical structure C6H9N3O3 SVG | 2D structure Metronidazole chemical names, chemical properties, classification C6H9N3O3