Diovan

Diovan (trade name Diovan®) is an angiotensin II receptor antagonist, acting on the AT1 subtype. In the U.S., valsartan is indicated for treatment of high blood pressure, of congestive heart failure (CHF), and post-myocardial infarction (MI). In 2005, Diovan® was prescribed more than 12 million times in the United States.

Medicinal name:
  • Valsartan 320 MG Oral Tablet [Diovan]
  • Valsartan 80 MG Oral Tablet [Diovan]
  • Hydrochlorothiazide 12.5 MG / valsartan 320 MG Oral Tablet [Diovan HCT]
  • Valsartan 160 MG Oral Tablet [Diovan]
  • Hydrochlorothiazide 25 MG / valsartan 160 MG Oral Tablet [Diovan HCT]
  • Hydrochlorothiazide 12.5 MG / valsartan 160 MG Oral Tablet [Diovan HCT]
  • Hydrochlorothiazide 12.5 MG / valsartan 80 MG Oral Tablet [Diovan HCT]
  • Hydrochlorothiazide 25 MG / valsartan 320 MG Oral Tablet [Diovan HCT]
  • Valsartan 40 MG Oral Tablet [Diovan]

Diovan - Pharmacology:

Diovan competes with angiotensin II for binding at the AT1 receptor subtype. As angiotensin II is a vasoconstrictor which also stimulates the synthesis and release of aldosterone, blockage of its effects results in a decreases in systemic vascular resistance.

Diovan mini report

Diovan NDA
NDA - A product marketed under an approved New Drug Application
Diovan HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Start - Stop data
START DATA:
2001-Jul-01
Start - Stop data
STOP DATA
not occurred

Diovan Interactions

No clinically significant pharmacokinetic interactions were observed when valsartan was coadministered with amlodipine, atenolol, cimetidine, digoxin, furosemide, glyburide, hydrochlorothiazide, or indomethacin. The valsartan-atenolol combination was more antihypertensive than either component, but it did not lower the heart rate more than atenolol alone.

Coadministration of valsartan and warfarin did not change the pharmacokinetics of valsartan or the time-course of the anticoagulant properties of warfarin.

CYP 450 Interactions: The enzyme(s) responsible for valsartan metabolism have not been identified but do not seem to be CYP 450 isozymes. The inhibitory or induction potential of valsartan on CYP 450 is also unknown.

As with other drugs that block angiotensin II or its effects, concomitant use of potassium sparing diuretics (e.g. spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine.

Diovan Contraindications

Diovan® (valsartan) is contraindicated in patients who are hypersensitive to any component of this product.

Manufacturers name:

  • Physicians Total Care, Inc
  • Novartis Pharmaceuticals Corporation
  • Cardinal Health
  • PD-Rx Pharmaceuticals, Inc
  • Bryant Ranch Prepack
  • REMEDYREPACK INC
  • Rebel Distributors Corp
  • Aphena Pharma Solutions - Tennessee, LLC
  • Lake Erie Medical DBA Quality Care Products LLC
  • Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC
  • Carilion Materials Management
  • Dispensing Solutions, Inc
  • STAT RX USA LLC

Generic name, Overdose, Half Life Diovan, Food Interactions, Chemical, etc..

Diovan see also FDA report Barrenwort

Brand Names containing Valsartan
Blood Pressure