Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk
of lithium toxicity. Read circulars for lithium preparations before use of such concomitant therapy.
EDECRIN may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin
antibiotics. Their concurrent use should be avoided.
A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein; a
reduction in the usual anticoagulant dosage may be required in patients receiving both drugs.
In some patients, the administration of a non- steroidal antiinflammatory agent can reduce the diuretic,
natriuretic, and antihypertensive effects of loop, potassium- sparing and thiazide diuretics. Therefore, when EDECRIN
and non- steroidal anti- inflammatory agents are used concomitantly, the patient should be observed closely to
determine if the desired effect of the diuretic is obtained.