Epivir-HBV Indication:

For the treatment of HIV infection and chronic hepatitis B (HBV).

Epivir-HBV Mechanism Of Action:

Epivir-HBV is a synthetic nucleoside analogue and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP). This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase and HBV polymerase, resulting in DNA chain termination.

Epivir-HBV Drug Interactions:

Zalcitabine Epivir-HBV decreases the efficacy of zalcitabine

Epivir-HBV Food Interactions:

Take without regard to meals. Food does not decrease the extent of absorption, but it decreases the Cmax by slowing the rate of absorption.

Epivir-HBV Generic Name:


  • Lamivudine [Usan:Ban:Inn]

Drug Type:

Small Molecule; Approved


Lamivudine was rapidly absorbed after oral administration in HIV-infected patients. Absolute bioavailability in adults is 86% ± 16% for the tablet and 87% ± 13% for the oral solution.

Toxicity (Overdose):

Not Available

Protein Binding:



The only detected metabolite of lamivudine is trans-sulfoxide.

Half Life:

5 to 7 hours

Dosage Forms of Epivir-HBV:

Tablet Oral
Solution Oral

Chemical IUPAC Name:


Organisms Affected:

Human Immunodeficiency Virus; Hepatitis B virus

Epivir-HBV to general, pharmacology

General, pharmacology..
Anti Viral