An ergot alkaloid (ergot alkaloids) with uterine and vascular smooth muscle contractile properties. .

Ergotrate - Pharmacology:

Ergotrate directly stimulates the uterine muscle to increase force and frequency of contractions. With usual doses, these contractions precede periods of relaxation; with larger doses, basal uterine tone is elevated and these relaxation periods will be decreased. Contraction of the uterine wall around bleeding vessels at the placental site produces hemostasis. Ergotrate also induces cervical contractions. The sensitivity of the uterus to the oxytocic effect is much greater toward the end of pregnancy. The oxytocic actions of ergonovine are greater than its vascular effects. Ergotrate, like other ergot alkaloids, produces arterial vasoconstriction by stimulation of alpha-adrenergic and serotonin receptors and inhibition of endothelial-derived relaxation factor release. It is a less potent vasoconstrictor than ergotamine. As a diagnostic aid (coronary vasospasm), ergonovine causes vasoconstriction of coronary arteries.

Generic name, Overdose, Half Life Ergotrate, Food Interactions, Chemical, etc..

Ergotrate see also

Chemical structure:
N N N O O H H H H H H H H H H H H H H H H H H H H H H H C19H23N3O2 2D chemical structure C19H23N3O2 SVG | 2D structure Ergonovine chemical names, chemical properties, classification C19H23N3O2