Exelon

Exelon is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer s type. Exelon is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.

Medicinal name:
  • Rivastigmine 3 MG Oral Capsule [Exelon]
  • Rivastigmine 4.5 MG Oral Capsule [Exelon]
  • Rivastigmine 1.5 MG Oral Capsule [Exelon]
  • Rivastigmine 6 MG Oral Capsule [Exelon]

Exelon - Pharmacology:

Exelon increases the concentration of acetylcholine through reversible inhibition of its hydrolysis by cholinesterase. This acts to enhance cholinergic function.

Exelon mini report

Exelon NDA
NDA - A product marketed under an approved New Drug Application
Exelon ORAL
ORAL
Exelon TRANSDERMAL
TRANSDERMAL
Exelon CAPSULE
CAPSULE
Exelon PATCH, EXTENDED RELEASE
PATCH, EXTENDED RELEASE
Exelon HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Exelon global name
rivastigmine tartrate
Exelon global name
rivastigmine
Start - Stop data
START DATA:
2000-Apr-30
Start - Stop data
STOP DATA
not occurred

Exelon for patients

Caregivers should be advised of the high incidence of nausea and vomiting associated with the use of the drug along with the possibility of anorexia and weight loss. Caregivers should be encouraged to monitor for these adverse events and inform the physician if they occur. It is critical to inform caregivers that if therapy has been interrupted for more than several days, the next dose should not be administered until they have discussed this with the physician.

Exelon Interactions

Drug-Drug Interactions

Effect of Exelon® (rivastigmine tartrate) on the Metabolism of Other Drugs: Exelon is primarily metabolized through hydrolysis by esterases. Minimal metabolism occurs via the major cytochrome P450 isoenzymes. Based on in vitro studies, no pharmacokinetic drug interactions with drugs metabolized by the following isoenzyme systems are expected: CYP1A2, CYP2D6, CYP3A4/5, CYP2E1, CYP2C9, CYP2C8, or CYP2C19. No pharmacokinetic interaction was observed between rivastigmine and digoxin, warfarin, diazepam, or fluoxetine in studies in healthy volunteers. The elevation of prothrombin time induced by warfarin is not affected by administration of Exelon.

Effect of Other Drugs on the Metabolism of Exelon: Drugs that induce or inhibit CYP450 metabolism are not expected to alter the metabolism of rivastigmine. Single dose pharmacokinetic studies demonstrated that the metabolism of rivastigmine is not significantly affected by concurrent administration of digoxin, warfarin, diazepam, or fluoxetine. Population PK analysis with a database of 625 patients showed that the pharmacokinetics of rivastigmine were not influenced by commonly prescribed medications such as antacids (n=77), antihypertensives (n=72), β-blockers (n=42), calcium channel blockers (n=75), antidiabetics (n=21), nonsteroidal anti-inflammatory drugs (n=79), estrogens (n=70), salicylate analgesics (n=177), antianginals (n=35), and antihistamines (n=15).

Use with Anticholinergics: Because of their mechanism of action, cholinesterase inhibitors have the potential to interfere with the activity of anticholinergic medications.

Use with Cholinomimetics and Other Cholinesterase Inhibitors: A synergistic effect may be expected when cholinesterase inhibitors are given concurrently with succinylcholine, similar neuromuscular blocking agents or cholinergic agonists such as bethanechol.

Exelon Contraindications

Exelon® (rivastigmine tartrate) is contraindicated in patients with known hypersensitivity to rivastigmine, other carbamate derivatives or other components of the formulation.

Manufacturers name:

  • Novartis Pharmaceuticals Corporation
  • Physicians Total Care, Inc

Generic name, Overdose, Half Life Exelon, Food Interactions, Chemical, etc..

Exelon see also Saw Palmetto

General health

Chemical structure:
+ N _ O O N H H H H H H H H H H H H H H H H H H H H H H C14H22N2O2 2D chemical structure C14H22N2O2 SVG | 2D structure Rivastigmine chemical names, chemical properties, classification C14H22N2O2