One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. .

Most likely, Fansidar - a mixture:
Fansidar Tablets (Pyrimethamine + Sulfadoxine)

Fansidar - Pharmacology:

Fansidar inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver.

Fansidar for patients

Patients should be warned that at the first appearance of a skin rash they should stop use of Fansidar and seek medical attention immediately. Patients should also be warned that the appearance of sore throat, pallor, purpura, or glossitis may be early indications of serious disorders which require treatment with Fansidar to be stopped and medical treatment to be sought.

Women of childbearing potential who are taking Fansidar should be warned against becoming pregnant. Patients should be warned to keep DARAPRIM out of the reach of children. Patients should be advised not to exceed recommended doses. Patients should be warned that if anorexia and vomiting occur, they may be minimized by taking the drug with meals.

Concurrent administration of folinic acid is strongly recommended when used for the treatment of toxoplasmosis in all patients.

Fansidar Interactions

Fansidar may be used with sulfonamides, quinine and other antimalarials, and with other antibiotics. However, the concomitant use of other antifolic drugs or agents associated with myelosuppression including sulfon-amides or trimethoprim-sulfamethoxazole combinations, proguanil, zidovudine, or cytostatic agents (e.g., methotrex-ate) while the patient is receiving pyrimethamine, may increase the risk of bone marrow suppression. If signs of folate deficiency develop, pyrimethamine should be discontinued. Folinic acid (leucovorin) should be administered until normal hematopoiesis is restored. Mild hepatotoxicity has been reported in some patients when lorazepam and pyrimethamine were administered concomitantly.

Fansidar Contraindications

Use of DARAPRIM is contraindicated in patients with known hypersensitivity to pyrimethamine or to any component of the formulation. Use of the drug is also contraindicated in patients with documented megaloblastic anemia due to folate deficiency.

Generic name, Overdose, Half Life Fansidar, Food Interactions, Chemical, etc..

Fansidar see also

Brand Names containing Pyrimethamine

Chemical structure:
N N Cl N N H H H H H H H H H H H H H C12H13ClN4 2D chemical structure C12H13ClN4 SVG | 2D structure Pyrimethamine chemical names, chemical properties, classification C12H13ClN4