A nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections. .

Fasigyn - Pharmacology:

Fasigyn is an antiprotozoal agent. The nitro group of tinidazole is reduced by cell extracts of Trichomonas. The free nitro radical generated as a result of this reduction may be responsible for the antiprotozoal activity. The mechanism by which tinidazole exhibits activity against Giardia and Entamoeba species is not known.

Fasigyn for patients

Tindamax tablets should be taken with food. Alcoholic beverages should be avoided while taking Tindamax and for three days afterward.

Fasigyn Interactions

Drug interactions:

Although not studied specifically for tinidazole, the following drug interactions were reported for metronidazole, a chemically-related nitroimidazole. Therefore, these drug interactions may occur with tinidazole.

Potential effect of tinidazole on other drugs

Warfarin and other oral coumarin anticoagulants. As with other nitroimidazole derivatives, tinidazole may enhance the effect of warfarin and other coumarin anticoagulants, resulting in a prolongation of prothrombin time. This potential interaction should be considered when tinidazole is prescribed for patients on this type of anticoagulant therapy. The dosage of oral anticoagulants may need to be adjusted during tinidazole co-administration and up to 8 days after discontinuation.

Alcohols, Disulfiram. Alcoholic beverages and preparations containing ethanol or propylene glycol should be avoided during tinidazole therapy and for three days afterward because abdominal cramps, nausea, vomiting, headaches and flushing may occur. Psychotic reactions have been reported in alcoholic patients using metronidazole and disulfiram concurrently. Though no similar reactions have been reported with tinidazole, tinidazole should not be given to patients who have taken disulfiram within the last two weeks.

Lithium. Metronidazole has been reported to elevate serum lithium levels. It is not known if tinidazole shares this property with metronidazole, but consideration should be given to measuring serum lithium and creatinine levels after several days of simultaneous lithium and tinidazole treatment to detect potential lithium intoxication.

Phenytoin, Fosphenytoin. Fosphenytoin is a pro-drug of phenytoin. Concomitant administration of oral metronidazole and intravenous phenytoin was reported to result in prolongation of the half-life and reduction in the clearance of phenytoin. Metronidazole did not significantly affect the pharmacokinetics of orally-administered phenytoin.

Cyclosporine, Tacrolimus. There are several case reports suggesting that metronidazole has the potential to increase the levels of cyclosporine and tacrolimus. During tinidazole co-administration with either of these drugs, the patient should be monitored for signs of calcineurin-inhibitor associated toxicities.

Fluorouracil. Metronidazole was shown to decrease the clearance of fluorouracil, resulting in an increase in side-effects without an increase in therapeutic benefits. If the concomitant use of tinidazole and fluorouracil cannot be avoided, the patient should be monitored for fluorouracil-associated toxicities.

Potential effect of other drugs on tinidazole

Simultaneous administration of tinidazole with drugs that induce liver microsomal enzymes (cytochrome P-450) such as phenobarbital, rifampin, phenytoin and fosphenytoin (a pro-drug of phenytoin) may accelerate the elimination of tinidazole, decreasing the plasma level of tinidazole. Simultaneous administration of drugs that inhibit the activity of liver microsomal enzymes, such as cimetidine and ketoconazole, may prolong the half-life and decrease the plasma clearance of tinidazole, increasing the plasma level of tinidazole.

Cholestyramine. Cholestyramine was shown to decrease the oral bioavailability of metronidazole by 21%. Thus, it is advisable to separate dosing of cholestyramine and tinidazole to minimize any potential effect on the oral bioavailability of tinidazole.

Oxytetracycline. Oxytetracycline was reported to antagonize the therapeutic effect of metronidazole.

Drug/Laboratory test interactions: Fasigyn, like metronidazole, may interfere with certain types of determinations of serum chemistry values, such as aspartate aminotransferase (AST, SGOT), alanine aminotransferase (ALT, SGPT), lactate dehydrogenase (LDH), triglycerides, and hexokinase glucose. Values of zero may be observed. All of the assays in which interference has been reported involve enzymatic coupling of the assay to oxidation-reduction of nicotinamide adenine dinucleotide (NAD + [harr ] NADH). Potential interference is due to the similarity of absorbance peaks of NADH and tinidazole.

Fasigyn Contraindications

Tindamax (tinidazole) is contraindicated in patients with hypersensitivity to tinidazole, any component of the tablet, or other nitroimidazole derivatives. Tindamax is contraindicated during the first trimester of pregnancy.

Generic name, Overdose, Half Life Fasigyn, Food Interactions, Chemical, etc..

Fasigyn see also

Brand Names containing Tinidazole

Chemical structure:
S O O O O N N N H H H H H H H H H H H H H C8H13N3O4S 2D chemical structure C8H13N3O4S SVG | 2D structure Tinidazole chemical names, chemical properties, classification C8H13N3O4S