A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. .

Medicinal name:
  • Piroxicam 20 MG Oral Capsule [Feldene]
  • Piroxicam 20 MG Oral Capsule
  • Piroxicam 10 MG Oral Capsule [Feldene]

Feldene - Pharmacology:

The antiinflammatory effect of Feldene may result from the reversible inhibition of cyclooxygenase, causing the peripheral inhibition of prostaglandin synthesis. The prostaglandins are produced by an enzyme called Cox-1. Feldene blocks the Cox-1 enzyme, resulting into the disruption of production of prostaglandins. Feldene also inhibits the migration of leukocytes into sites of inflammation and prevents the formation of thromboxane A2, an aggregating agent, by the platelets.

Feldene mini report

Feldene ANDA
ANDA - A product marketed under an approved Abbreviated New Drug Application
Feldene NDA
NDA - A product marketed under an approved New Drug Application
Feldene global name
Feldene global name
Start - Stop data
Start - Stop data
not occurred

Feldene for patients

FELDENE, like other drugs of its class, is not free of side effects. The side effects of these drugs can cause discomfort and rarely, there are more serious side effects, such as gastrointestinal bleeding, which may result in hospitalization and even fatal outcomes.

NSAIDs (Nonsteroidal Anti-Inflammatory Drugs) are often essential agents in the management of arthritis, but they also may be commonly employed for conditions which are less serious.

Physicians may w.s. to discuss with their patients the potential risks and likely benefits of NSAID treatment, particularly when the drugs are used for less serious conditions where treatment without NSAIDs may represent an acceptable alternative to both the patient and physician.

Feldene Interactions

FELDENE is highly protein bound, and therefore, might be expected to displace other protein-bound drugs. Although this has not occurred in in vitro studies with coumarin-type anticoagulants, interactions with coumarin-type anticoagulants have been reported with FELDENE since marketing, therefore, physicians should closely monitor patients for a change in dosage requirements when administering FELDENE to patients on coumarin-type anticoagulants and other highly protein-bound drugs.

Plasma levels of piroxicam are depressed to approximately 80% of their normal values when FELDENE is administered in conjunction with aspirin (3900 mg/day), but concomitant administration of antacids has no effect on piroxicam plasma levels .

Nonsteroidal anti-inflammatory agents, including FELDENE, have been reported to increase steady state plasma lithium levels. It is recommended that plasma lithium levels be monitored when initiating, adjusting and discontinuing FELDENE.

Feldene Contraindications

FELDENE should not be used in patients who have previously exhibited hypersensitivity to it, or in individuals with the syndrome comprised of bronchospasm, nasal polyps, and angioedema precipitated by aspirin or other nonsteroidal anti-inflammatory drugs.

Manufacturers name:

  • Pfizer Laboratories Div Pfizer Inc
  • Keltman Pharmaceuticals Inc

Generic name, Overdose, Half Life Feldene, Food Interactions, Chemical, etc..

Feldene see also FDA report Ashwagandha

Brand Names containing Piroxicam

Chemical structure:
+ N _ O O S O O N N H H H H H H H H H H H H H C15H13N3O4S 2D chemical structure C15H13N3O4S SVG | 2D structure Piroxicam chemical names, chemical properties, classification C15H13N3O4S