An analogue of gamma-aminobutyric acid. It is an irreversible inhibitor of 4-aminobutyrate transaminase, the enzyme responsible for the catabolism of gamma-aminobutyric acid. (From Martindale The Extra Pharmacopoeia, 31st ed)

GVG - Pharmacology:

It is believed that vigabatrin increases brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by irreversibly inhibiting enzymes that catabolize GABA (gamma-aminobutyric acid transaminase GABA-T) or block the reuptake of GABA into glia and nerve endings. GVG may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels.

GVG for patients

This medicine may reduce your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you and you are sure it wont affect your performance. Avoid stopping this medicine suddenly. The dose of this medicine should be gradually decreased over a period of two to four weeks. After months to years of taking this medication, damage to vision may occur. Regular eye examinations should be conducted and notify your doctor if any change in vision occurs.

GVG Interactions

A study published in 2002 found that vigabatrin causes a statistically significant increase in plasma clearance of carbamazepine. In 1984, Drs Rimmer and Richens at the University of Wales reported that administering vigabatrin with phenytoin lowered the serum phenytoin concentration in patients with treatment-resistant epilepsy. The concentration of phenytoin falls to 23% within five weeks, according to an experiment published in 1989 by the same two scientists that tried and failed to elucidate the mechanism behind this interaction.

GVG Contraindications

In pregnancy and lactation and in patients with a known hypersensitivity to vigabatrin or to any components of the product.

Generic name, Overdose, Half Life GVG, Food Interactions, Chemical, etc..

GVG see also

Brand Names containing Vigabatrin

Chemical structure:
O O N H H H H H H H H H H H C6H11NO2 2D chemical structure C6H11NO2 SVG | 2D structure Vigabatrin | (4e)-4-Aminohex-4-Enoic Acid | Cycloleucine | chemical names, chemical properties, classification C6H11NO2