Glucophage Indication:

For use as an adjunct to diet and exercise to improve glycemic control in adult patients (18 years and older) with type 2 diabetes.

Glucophage Mechanism Of Action:

Glucophage's pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents. Glucophage decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

Glucophage Drug Interactions:

Cimetidine Cimetidine increases the effect of metformin
Glucosamine Possible hyperglycemia

Glucophage Food Interactions:

Avoid alcohol.
Take with food.

Glucophage Generic Name:

Synonyms:

  • Metformin HCL
  • metformin hydrochloride

Drug Type:

Small Molecule; Approved

Absorption:

Absorbed over 6 hours, bioavailability is 50 to 60% under fasting conditions. Food delays absorption.

Toxicity (Overdose):

Acute oral toxicity (LD50): 350 mg/kg [Rabbit]. It would be expected that adverse reactions of a more intense character including epigastric discomfort, nausea, and vomiting followed by diarrhea, drowsiness, weakness, dizziness, malaise and headache might be seen.

Protein Binding:

Metformin is negligibly bound to plasma proteins.

Biotransformation:

Metformin is not metabolized.

Half Life:

6.2 hours

Dosage Forms of Glucophage:

Tablet, extended release Oral
Tablet Oral

Chemical IUPAC Name:

3-(diaminomethylidene)-1,1-dimethylguanidine

Organisms Affected:

Humans and other mammals

Glucophage to general, pharmacology

General, pharmacology..