Glyde

A broad-spectrum antibiotic derived from kanamycin. It is reno- and oto-toxic like the other aminoglycoside antibiotics. ..

Glyde - Pharmacology:

Aminoglycosides like Glyde "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Glyde inhibits protein synthesis by binding to the 30S ribosomal subunit to prevent the formation of an initiation complex with messenger RNA. Specifically Glyde binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.

Glyde for patients

Patient Information:

Glyde is potentially nephrotoxic, ototoxic and neurotoxic. Patient should
drink more fluid to minimize the chemical irritation to the kidney. Renal
function should be monitored before and during the course of the treatment.

Glyde-induced ototoxicity is usually irreversible. Patient may not have any
symptoms. Patient may experience numbness, tingling, muscle twitching and
convultions because of the neurotoxicity.

If patient experiences any unusual signs or symptoms, please contact you doctor
immediately.

Glyde Interactions

No information provided.

Glyde Contraindications

A history of hypersensitivity to amikacin is a contraindication for its use. A history of hypersensitivity or serious toxic reactions to aminoglycosides may contraindicate the use of any other aminoglycoside because of the known cross-sensitivities of patients to drugs in this class.

Generic name, Overdose, Half Life Glyde, Food Interactions, Chemical, etc..

Glyde see also

Brand Names containing Amikacin

Chemical structure:
O O O O O O O O O O O O N N N N N O H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H C22H43N5O13 2D chemical structure C22H43N5O13 SVG | 2D structure chemical names, chemical properties, classification C22H43N5O13