Haloperidol Decanoate

A phenyl-piperidinyl-butyrophenone that is used primarily to treat schizophrenia and other psychoses. It is also used in schizoaffective disorder, delusional disorders, ballism, and tourette syndrome (a drug of choice) and occasionally as adjunctive therapy in mental retardation and the chorea of huntington disease. It is a potent antiemetic and is used in the treatment of intractable hiccups. (From AMA Drug Evaluations Annual, 1994, p279)

Medicinal name:
  • Haloperidol 2 MG Oral Tablet
  • Haloperidol 10 MG Oral Tablet
  • Haloperidol 20 MG Oral Tablet
  • Haloperidol 5 MG Oral Tablet
  • Haloperidol 1 MG Oral Tablet
  • Haloperidol 0.5 MG Oral Tablet

Haloperidol Decanoate - Pharmacology:

The precise mechanism whereby the therapeutic effects of haloperidol are produced is not known. Its effect on the central nervous system is thought to be associated with the competitive blockade of postsynaptic dopamine D2 receptors in the mesolimbic dopaminergic system and an increased turnover rate of brain dopamine.

Haloperidol Decanoate mini report

Haloperidol Decanoate ANDA
ANDA - A product marketed under an approved Abbreviated New Drug Application
Haloperidol Decanoate NDA AUTHORIZED GENERIC
NDA AUTHORIZED GENERIC - A product marketed as a “generic” drug under an approved NDA, rather than an ANDA
Haloperidol Decanoate HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Haloperidol Decanoate global name
Haloperidol Decanoate
Haloperidol Decanoate global name
HALOPERIDOL DECANOATE
Start - Stop data
START DATA:
1999-Jun-04
Start - Stop data
STOP DATA
not occurred

Haloperidol Decanoate Interactions

An encephalopathic syndrome (characterized by weakness, lethargy, fever, tremulousness and confusion, extrapyramidal symptoms, leukocytosis, elevated serum enzymes, BUN, and FBS) followed by irreversible brain damage has occurred in a few patients treated with lithium plus HALDOL. A causal relationship between these events and the concomitant administration of lithium and HALDOL has not been established; however, patients receiving such combined therapy should be monitored closely for early evidence of neurological toxicity and treatment discontinued promptly if such signs appear.

As with other antipsychotic agents, it should be noted that HALDOL may be capable of potentiating CNS depressants such as anesthetics, opiates, and alcohol.

In a study of 12 schizophrenic patients coadministered oral haloperidol and rifampin, plasma haloperidol levels were decreased by a mean of 70% and mean scores on the Brief Psychiatric Rating Scale were increased from baseline. In 5 other schizophrenic patients treated with oral haloperidol and rifampin, discontinuation of rifampin produced a mean 3.3-fold increase in haloperidol concentrations. Thus, careful monitoring of clinical status is warranted when rifampin is administered or discontinued in haloperidol-treated patients.

Haloperidol Decanoate Contraindications

Since the pharmacologic and clinical actions of HALDOL Decanoate 50 and HALDOL Decanoate 100 are attributed to HALDOL (haloperidol) as the active medication, Contraindications, Warnings, and additional information are those of HALDOL, modified only to reflect the prolonged action. HALDOL is contraindicated in severe toxic central nervous system depression or comatose states from any cause and in individuals who are hypersensitive to this drug or have Parkinsonís disease.

Manufacturers name:

  • Mylan Pharmaceuticals Inc
  • Sandoz Inc
  • State of Florida DOH Central Pharmacy
  • REMEDYREPACK INC
  • NCS HealthCare of KY, Inc dba Vangard Labs
  • Zydus Pharmaceuticals (USA) Inc
  • Cadila Healthcare Limited
  • Cardinal Health
  • Mylan Institutional Inc
  • TYA Pharmaceuticals
  • Physicians Total Care, Inc
  • Clinical Solutions Wholesale
  • Contract Pharmacy Services-PA
  • American Health Packaging
  • PD-Rx Pharmaceuticals, Inc
  • Major Pharmaceuticals
  • Lake Erie Medical DBA Quality Care Products LLC
  • DIRECT RX
  • Dispensing Solutions, Inc
  • Rebel Distributors Corp
  • McKesson Contract Packaging

Generic name, Overdose, Half Life Haloperidol Decanoate, Food Interactions, Chemical, etc..

Haloperidol Decanoate see also


Chemical structure:
F O N Cl O H H H H H H H H H H H H H H H H H H H H H H H C21H23ClFNO2 2D chemical structure C21H23ClFNO2 SVG | 2D structure chemical names, chemical properties, classification C21H23ClFNO2