A benzenesulfonamide-phthalimidine that tautomerizes to a benzophenones form. It is considered a thiazide-like diuretic. .

Higroton - Pharmacology:

Higroton inhibits sodium ion transport across the renal tubular epithelium in the cortical diluting segment of the ascending limb of the loop of Henle. By increasing the delivery of sodium to the distal renal tubule, Higroton indirectly increases potassium excretion via the sodium-potassium exchange mechanism.

Higroton for patients

Patients should inform their physician if they have: (1) had an allergic reaction to chlorthalidone or other diuretics or have asthma, (2) kidney disease, (3) liver disease, (4) gout, (5) systemic lupus erythematosus, or (6) been taking other drugs such as cortisone, digitalis, lithium carbonate, or drugs for diabetes.

Patients should be cautioned to contact their physician if they experience any of the following symptoms of potassium loss: excess thirst, tiredness, drowsiness, restlessness, muscle pains or cramps, nausea, vomiting, or increased heart rate or pulse.

Patients should also be cautioned that taking alcohol can increase the chance of dizziness occurring.

Higroton Interactions

Higroton may add to or potentiate the action of other antihypertensive drugs. Potentiation occurs with ganglionic peripheral adrenergic blocking drugs.

Medication such as digitalis may also influence serum electrolytes. Warning signs, irrespective of cause, are: dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting.

Insulin requirements in diabetic patients may be increased, decreased, or unchanged. Higher dosage of oral hypoglycemic agents may be required. Latent diabetes mellitus may become manifest during chlorthalidone administration.

Higroton and related drugs may increase the responsiveness to tubocurarine.

Higroton and related drugs may decrease arterial responsiveness to norepinephrine. This diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use.

Higroton Contraindications


Known hypersensitivity to chlorthalidone or other sulfonamide-derived drugs.

Generic name, Overdose, Half Life Higroton, Food Interactions, Chemical, etc..

Higroton see also Barrenwort

Brand Names containing Chlorthalidone
Blood Pressure

Chemical structure:
Cl N H O O S O O N H H H H H H H H H H C14H11ClN2O4S 2D chemical structure C14H11ClN2O4S SVG | 2D structure Chlorthalidone chemical names, chemical properties, classification C14H11ClN2O4S