Human, recombinant GM-CSF, expressed in yeast. Glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.

Immunex - Pharmacology:

Immunex binds to the Granulocyte-macrophage colony stimulating factor receptor (GM-CSF-R-alpha or CSF2R) which stimulates a JAK2 STAT1/STAT3 signal transduction pathway. This leads to the production of hemopoietic cells and neutrophils

Immunex Interactions

Interactions between Leukine and other drugs have not been fully evaluated. Drugs which may potentiate the myeloproliferative effects of Leukine, such as lithium and corticosteroids, should be used with caution.

Immunex Contraindications

Leukine is contraindicated:

1) in patients with excessive leukemic myeloid blasts in the bone marrow or peripheral blood (3 10%).

2) in patients with known hypersensitivity to GM-CSF, yeast-derived products or any component of the product.

3) for concomitant use with chemotherapy and radiotherapy.

Due to the potential sensitivity of rapidly dividing hematopoietic progenitor cells, Leukine should not be administered simultaneously with cytotoxic chemotherapy or radiotherapy or within 24 hours preceding or following chemotherapy or radiotherapy. In one controlled study, patients with small cell lung cancer received Leukine and concurrent thoracic radiotherapy and chemotherapy or the identical radiotherapy and chemotherapy without Leukine. The patients randomized to Leukine had significantly higher incidence of adverse events, including higher mortality and a higher incidence of grade 3 and 4 infections and grade 3 and 4 thrombocytopenia.11

Generic name, Overdose, Half Life Immunex, Food Interactions, Chemical, etc..

Immunex see also

Brand Names containing Sargramostim