Keflex

A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of cephaloridine or cephalothin, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms. .
[PubChem].

Medicinal name:
  • Cephalexin 750 MG Oral Capsule [Keflex]
  • Keflex 750 MG Oral Capsule
  • Keflex 500 MG Oral Capsule
  • Cephalexin 250 MG Oral Capsule [Keflex]
  • Cephalexin 500 MG Oral Capsule [Keflex]
  • Cephalexin 333 MG Oral Capsule [Keflex]
  • Keflex 250 MG Oral Capsule

Keflex - Pharmacology:

Keflex, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cephalexin interferes with an autolysin inhibitor.

Keflex mini report

Keflex ANDA
ANDA - A product marketed under an approved Abbreviated New Drug Application
Keflex NDA
NDA - A product marketed under an approved New Drug Application
Keflex HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Keflex global name
CEPHALEXIN
Keflex global name
cephalexin
Start - Stop data
START DATA:
2016-May-02
Start - Stop data
STOP DATA
not occurred

Keflex for patients

Patients should be counseled that antibacterial drugs including Keflex should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When Keflex is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Keflex or other antibacterial drugs in the future.

Keflex Interactions

Metformin In healthy subjects given single 500 mg doses of cephalexin and metformin, plasma metformin mean cmax and AUC increased by an average of 34% and 24%, respectively, and metformin mean renal clearance decreased by 14%. No information is available about the interaction of cephalexin and metformin following multiple doses of either drug.

Although not observed in this study, adverse effects could potentially arise from co-administration of cephalexin and metformin by inhibition of tubular secretion via organic cationic transporter systems. Accordingly, careful patient monitoring and dose adjustment of metformin is recommended in patients concomitantly taking cephalexin and metformin.

Probenecid As with other b-lactams, the renal excretion of cephalexin is inhibited by probenecid.

Drug / Laboratory Test Interactions

As a result of administration of Keflex, a false-positive reaction for glucose in the urine may occur. This has been observed with Benedictís and Fehlingís solutions and also with Clinitest® tablets.

Keflex Contraindications

Keflex is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

Manufacturers name:

  • Shionogi Inc
  • Victory Pharma, Inc
  • ADVANCIS PHARMACEUTICAL CORPORATION

Keflex tags categories:

Generic name, Overdose, Half Life Keflex, Food Interactions, Chemical, etc..

Keflex see also FDA report

Antibiotics

Chemical structure:
N O S O O N N O H H H H H H H H H H H H H H H H H C16H17N3O4S 2D chemical structure C16H17N3O4S SVG | 2D structure Cephalexin chemical names, chemical properties, classification C16H17N3O4S