Lanoxin

A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone digoxigenin. Lanoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)

Medicinal name:
  • Digoxin 0.25 MG Oral Tablet [Lanoxin]
  • Digoxin 0.125 MG Oral Tablet [Lanoxin]
  • Lanoxin 250 MCG Oral Tablet
  • Lanoxin 0.125 MG Oral Tablet
  • Digoxin 0.0625 MG Oral Tablet [Lanoxin]
  • Digoxin 0.1875 MG Oral Tablet [Lanoxin]

Lanoxin - Pharmacology:

Lanoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Lanoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.

Lanoxin mini report

Lanoxin NDA
NDA - A product marketed under an approved New Drug Application
Lanoxin INTRAMUSCULAR; INTRAVENOUS
INTRAMUSCULAR; INTRAVENOUS
Lanoxin ORAL
ORAL
Lanoxin INJECTION, SOLUTION
INJECTION, SOLUTION
Lanoxin TABLET
TABLET
Lanoxin HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Start - Stop data
START DATA:
1985-Oct-01
Start - Stop data
STOP DATA
not occurred

Lanoxin for patients

Lanoxin is used for the treatment of congestive heart failure and for irregular heartbeat. Notify your physician if you are pregnant or nursing. Do not stop taking digoxin without talking with your physician. Lanoxin may be taken with or without food. It should be taken at approximately the same time each morning. Do not take over-the-counter antacids, cough, cold, allergy or diet medications without notifying your physician and pharmacist. Notify your physician if you develop an irregular heartbeat, trouble breathing, skin rash, nausea, diarrhea, blurred or yellow vision, or unusual weakness or tiredness.

Lanoxin Interactions

Potassium-depleting diuretics are a major contributing factor to digitalis toxicity. Calcium, particularly if administered rapidly by the intravenous route, may produce serious arrhythmias in digitalized patients. Quinidine, verapamil, amiodarone, propafenone, indomethacin, itraconazole, alprazolam, and spironolactone raise the serum digoxin concentration due to a reduction in clearance and/or in volume of distribution of the drug, with the implication that digitalis intoxication may result. Erythromycin and clarithromycin (and possibly other macrolide antibiotics) and tetracycline may increase digoxin absorption in patients who inactivate digoxin by bacterial metabolism in the lower intestine, so that digitalis intoxication may result. The risk of this interaction may be reduced if digoxin is given as capsules. Propantheline and diphenoxylate, by decreasing gut motility, may increase digoxin absorption. Antacids, kaolin-pectin, sulfasalazine, neomycin, cholestyramine, certain anticancer drugs, and metoclopramide may interfere with intestinal digoxin absorption, resulting in unexpectedly low serum concentrations. Rifampin may decrease serum digoxin concentration, especially in patients with renal dysfunction, by increasing the non-renal clearance of digoxin. There have been inconsistent reports regarding the effects of other drugs (e.g., quinine, penicillamine) on serum digoxin concentration. Thyroid administration to a digitalized, hypothyroid patient may increase the dose requirement of digoxin. Concomitant use of digoxin and sympathomimetics increases the risk of cardiac arrhythmias. Succinylcholine may cause a sudden extrusion of potassium from muscle cells, and may thereby cause arrhythmias in digitalized patients. Although beta-adrenergic blockers or calcium channel blockers and digoxin may be useful in combination to control atrial fibrillation, their additive effects on AV node conduction can result in advanced or complete heart block.

Due to the considerable variability of these interactions, the dosage of digoxin should be individualized when patients receive these medications concurrently. Furthermore, caution should be exercised when combining digoxin with any drug that may cause a significant deterioration in renal function, since a decline in glomerular filtration or tubular secretion may impair the excretion of digoxin.

Lanoxin Contraindications

Digitalis glycosides are contraindicated in patients with ventricular fibrillation or in patients with a known hypersensitivity to digoxin. A hypersensitivity reaction to other digitalis preparations usually constitutes a contraindication to digoxin.

Manufacturers name:

  • Cardinal Health
  • Aphena Pharma Solutions - Tennessee, LLC
  • GlaxoSmithKline LLC
  • Physicians Total Care, Inc
  • Rx Pak Division of McKesson Corporation
  • Covis Pharmaceuticals, Inc
  • REMEDYREPACK INC
  • PD-Rx Pharmaceuticals, Inc

Generic name, Overdose, Half Life Lanoxin, Food Interactions, Chemical, etc..

Lanoxin see also FDA report

Cardiovascular

Chemical structure:
O O O O O O O O O O O O O O H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H C41H64O14 2D chemical structure C41H64O14 SVG | 2D structure Digoxin chemical names, chemical properties, classification C41H64O14