Lorfast Indication:

For the relief of nasal and non-nasal symptoms of seasonal allergic rhinitis and for the treatment of chronic idiopathic urticaria in patients 2 years of age or older

Lorfast Mechanism Of Action:

Like other H1-blockers, loratadine competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Lorfast also has a weak affinity for acetylcholine and alpha-adrenergic receptors.

Lorfast Drug Interactions:

Nefazodone Increased risk of cardiotoxicity

Lorfast Food Interactions:

Take on empty stomach: 1 hour before or 2 hours after meals.

Lorfast Generic Name:

Synonyms:

  • Loratadina [Spanish]
  • Loratadinum [Latin]

Drug Type:

Small Molecule; Approved

Absorption:

Rapidly absorbed following oral administration (40% bioavailability)

Toxicity (Overdose):

somnolence, tachycardia, and headache LD50=mg/kg (orally in rat)

Protein Binding:

Not Available

Biotransformation:

Hepatic

Half Life:

8.4 hours

Dosage Forms of Lorfast:

Tablet Oral
Syrup Oral

Chemical IUPAC Name:

4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester

Organisms Affected:

Humans and other mammals

Lorfast to general, pharmacology

General, pharmacology..