A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes. .

Malation - Pharmacology:

Malation is a nonsystemic, wide-spectrum organophosphate insecticide. It inhibits acetylcholinesterase activity of most eukaryotes. Malation is toxic to aquatic organisms, but has a relatively low toxicity for birds and mammals. The major metabolites of malathion are mono- and di-carboxylic acid derivatives, and malaoxon is a minor metabolite. However, it is malaoxon that is the strongest cholinesterase inhibitor. Cholinesterases catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. Because of its essential function, chemicals that interfere with the action of cholinesterase are potent neurotoxins, causing muscle spasms and ultimately death.

Malation for patients

1. OVIDE Lotion is flammable. The lotion and hair wet with lotion should not be exposed to open flames or electric heat sources, including hair dryers and electric curlers. Do not smoke while applying lotion or while hair is wet. The person applying OVIDE Lotion should wash hands after application. Allow hair to dry naturally and to remain uncovered after application of OVIDE Lotion.

2. OVIDE Lotion should only be used on children under the direct supervision of an adult. Children should be warned to stay away from lighted cigarettes, open flames, and electric heat sources while the hair is wet.

3. In case of accidental ingestion of OVIDE Lotion by mouth, seek medical attention immediately.

4. If you are pregnant or nursing, you should contact your physician before using OVIDE Lotion.

5. If OVIDE Lotion comes into contact with the eyes, flush immediately with water. Consult a physician if eye irritation persists or if visual changes occur.

6. If skin irritation occurs, wash scalp and hair immediately. If the irritation clears, OVIDE Lotion may be reapplied. If irritation reoccurs, consult a physician.

7. Slight stinging sensations may be produced when using OVIDE Lotion.

8. Apply OVIDE Lotion on the scalp hair in an amount just sufficient to thoroughly wet hair and scalp. Pay particular attention to the back of the head and neck when applying OVIDE Lotion. Anyone applying OVIDE Lotion should wash hands immediately after the application process is complete.

9. Allow hair to dry naturally and to remain uncovered. Shampoo hair after 8 to 12 hours, again paying attention to the back of the head and neck while shampooing.

10.Rinse hair and use a fine-toothed (nit) comb to remove dead lice and eggs.

11.If lice are still present after 7-9 days, repeat with a second application of OVIDE Lotion. 12.Further treatment is generally not necessary. Other family members should be evaluated by a physician to determine if infested, and if so, receive treatment.

Malation Interactions

No information available.


Malation Contraindications

OVIDE Lotion is contraindicated for neonates and infants because their scalps are more permeable and may have increased absorption of malathion. OVIDE Lotion should also not be used on individuals known to be sensitive to malathion or any of the ingredients in the vehicle.

Generic name, Overdose, Half Life Malation, Food Interactions, Chemical, etc..

Malation see also

Chemical structure:
S O O S P O O O O H H H H H H H H H H H H H H H H H H H C10H19O6PS2 2D chemical structure C10H19O6PS2 SVG | 2D structure Malathion chemical names, chemical properties, classification C10H19O6PS2