Mannite

Mannite is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannite elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannite may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid.

Mannite - Pharmacology:

Mannite is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannite elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. As a diurectic mannitol induces diuresis because it is not reabsorbed in the renal tubule, thereby increasing the osmolality of the glomerular filtrate, facilitating excretion of water, and inhibiting the renal tubular reabsorption of sodium, chloride, and other solutes. Mannite promotes the urinary excretion of toxic materials and protects against nephrotoxicity by preventing the concentration of toxic substances in the tubular fluid. As an Antiglaucoma agent mannitol levates blood plasma osmolarity, resulting in enhanced flow of water from the eye into plasma and a consequent reduction in intraocular pressure. As a renal function diagnostic aid mannitol is freely filtered by the glomeruli with less than 10% tubular reabsorption. Therefore, its urinary excretion rate may serve as a measurement of glomerular filtration rate (GFR).

Mannite Interactions

No information provided.

 

Mannite Contraindications

OSMITROL Injection (Mannite Injection, USP) is contraindicated in patients with:

Well established anuria due to severe renal disease,
Severe pulmonary congestion or frank pulmonary edema,
Active intracranial bleeding except during craniotomy,
Severe dehydration,
Progressive renal damage or dysfunction after institution of mannitol therapy, including increasing oliguria and azotemia, and
Progressive heart failure or pulmonary congestion after institution of mannitol therapy.

Generic name, Overdose, Half Life Mannite, Food Interactions, Chemical, etc..

Mannite see also

Brand Names containing Mannitol

Chemical structure:
O O O O O O H H H H H H H H H H H H H H C6H14O6 2D chemical structure C6H14O6 SVG | 2D structure Mannitol | D-Sorbitol | chemical names, chemical properties, classification C6H14O6