Mannitol

Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid.


Most likely, Mannitol - a mixture:
Cystosol W 3% Hexitols (Mannitol + Sorbitol)

Mannitol - Pharmacology:

Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. As a diurectic mannitol induces diuresis because it is not reabsorbed in the renal tubule, thereby increasing the osmolality of the glomerular filtrate, facilitating excretion of water, and inhibiting the renal tubular reabsorption of sodium, chloride, and other solutes. Mannitol promotes the urinary excretion of toxic materials and protects against nephrotoxicity by preventing the concentration of toxic substances in the tubular fluid. As an Antiglaucoma agent mannitol levates blood plasma osmolarity, resulting in enhanced flow of water from the eye into plasma and a consequent reduction in intraocular pressure. As a renal function diagnostic aid mannitol is freely filtered by the glomeruli with less than 10% tubular reabsorption. Therefore, its urinary excretion rate may serve as a measurement of glomerular filtration rate (GFR).

Mannitol mini report

Mannitol ANDA
ANDA - A product marketed under an approved Abbreviated New Drug Application
Mannitol NDA
NDA - A product marketed under an approved New Drug Application
Mannitol INTRAVENOUS
INTRAVENOUS
Mannitol IRRIGATION
IRRIGATION
Mannitol INJECTION, SOLUTION
INJECTION, SOLUTION
Mannitol IRRIGANT
IRRIGANT
Mannitol HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Mannitol global name
mannitol
Mannitol global name
MANNITOL
Mannitol global name
Mannitol
Start - Stop data
START DATA:
1990-Sep-30
Start - Stop data
STOP DATA
not occurred

Mannitol Interactions

No information provided.

 

Mannitol Contraindications

OSMITROL Injection (Mannitol Injection, USP) is contraindicated in patients with:

Well established anuria due to severe renal disease,
Severe pulmonary congestion or frank pulmonary edema,
Active intracranial bleeding except during craniotomy,
Severe dehydration,
Progressive renal damage or dysfunction after institution of mannitol therapy, including increasing oliguria and azotemia, and
Progressive heart failure or pulmonary congestion after institution of mannitol therapy.

Generic name, Overdose, Half Life Mannitol, Food Interactions, Chemical, etc..

Mannitol see also


Chemical structure:
O O O O O O H H H H H H H H H H H H H H C6H14O6 2D chemical structure C6H14O6 SVG | 2D structure Mannitol | D-Sorbitol | chemical names, chemical properties, classification C6H14O6