A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis. .

Medicinal name:
  • Ibuprofen 200 MG Oral Capsule [Motrin]
  • Diphenhydramine Citrate 38 MG / Ibuprofen 200 MG Oral Tablet [Motrin PM]
  • Motrin 100 MG Oral Tablet
  • Motrin 100 MG Chewable Tablet
  • Ibuprofen 200 MG Oral Tablet [Motrin]
  • Motrin 200 MG Oral Tablet

Motrin - Pharmacology:

The exact mechanisms of action of Motrin is unknown. Its antiinflammatory effects are believed to be due to inhibition of both cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2) which leads to the inhibition of prostaglandin synthesis, and results in the inhibition of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.

Motrin mini report

Motrin NDA
NDA - A product marketed under an approved New Drug Application
Motrin ANDA
ANDA - A product marketed under an approved Abbreviated New Drug Application
Motrin global name
Motrin global name
Ibuprofen and Diphenhydramine Citrate
Start - Stop data
Start - Stop data
not occurred

Motrin for patients

Motrin is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation, reduce fever, and treat osteoarthritis, rheumatoid arthritis, and menstrual cramps. Inform your physician if you are pregnant or nursing. Motrin should not be taken during the last three months of pregnancy. Inform your physician if you use alcohol chronically. Motrin should not be taken with aspirin products. This medication should be taken with food, milk or antacids if stomach upset occurs. Motrin may cause dizziness and drowsiness; use caution while driving or operating hazardous machinery. Motrin may cause increased sensitivity to sunlight. Use sunscreens and wear protective clothing until degree of sensitivity is determined. Notify your physician if you develop stomach pain, bloody vomit, bloody or black tarry stools, cloudy urine, trouble breathing, rash or hives.

Motrin Interactions

Coumarin-Type Anticoagulants: Several short-term controlled studies failed to wshow that ibuprofen significantly affected prothrombin times or a variety of other clotting factors when administered to individuals on coumarin-type anticoagulants. However, because bleeding has been reported when ibuprofen and other nonsteroidal anti-inflammatory agents have been administered to patients on coumarin-type anticoagulants, the physician should be cautious when administering ibuprofen to patients on anticoagulants.

Aspirin: Animal studies wshow that aspirin given with nonsteroidal anti-inflammatory agents, including ibuprofen, yields a net decrease in anti-inflammatory activity with lowered blood levels of the non-aspirin drug. Single dose bioavailability studies in normal volunteers have failed to wshow an effect of aspirin on ibuprofen blood levels. Correlative clinical studies have not been performed.

Methotrexate: Motrin, as well as other nonsteroidal anti-inflammatory drugs, probably reduces the tubular secretion of methotrexate based on in vitro studies in rabbit kidney slices. This may indicate that ibuprofen could enhance the toxicity of methotrexate. Caution should be used if ibuprofen is administered concomitantly with methotrexate.

H-2 Antagonists: In studies with human volunteers, co-administration of cimetidine or ranitidine with ibuprofen had no substantive effect on ibuprofen serum concentrations.

Furosemide: Clinical studies, as well as random observations, have shown that ibuprofen can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with ibuprofen, the patient should be observed closely for signs of renal failure, as well as to assure diuretic efficacy.

Lithium: Motrin produced an elevation of plasma lithium levels and a reduction in renal lithium clearance in a study of eleven normal volunteers. The mean minimum lithium concentration increased 15% and the renal clearance of lithium was decreased by 19% during this period of concomitant drug administration.

This effect has been attributed to inhibition of renal prostaglandin synthesis by ibuprofen. Thus, when ibuprofen and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity. (Read circulars for lithium preparation before use of such concurrent therapy).

Motrin Contraindications

Motrin tablets or ibuprofen childrens suspension should not be used in patients who have previously exhibited hypersensitivity to the drug, or in individuals with the syndrome of nasal polyps, angioedema, and bronchospastic reactivity to aspirin or other nonsteroidal anti-inflammatory agents. Anaphylactoid reactions have occurred in such patients.

Manufacturers name:

  • McNeil Consumer Healthcare Div McNeil-PPC, Inc
  • Lil Drug Store Products, Inc

Generic name, Overdose, Half Life Motrin, Food Interactions, Chemical, etc..

Motrin see also FDA report Ashwagandha


Chemical structure:
O O H H H H H H H H H H H H H H H H H H C13H18O2 2D chemical structure C13H18O2 SVG | 2D structure Ibuprofen chemical names, chemical properties, classification C13H18O2