NICO is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. NICO is also important medically because of its presence in tobacco smoke. .

NICO - Pharmacology:

NICO binds to the nicotinic acetylcholine receptor. Stimulation of nicotinic receptors leads to a variety of cholinergic and adrenergic effects; tachycardia or bradycardia mediated by either stimulation or interference with sympathetic or parasympathetic pathways, stimulation of receptors in the carotic and aortic bodies, release of epinephrine from the adrenal medulla, and stimulation of the chemoreceptor-trigger zone.

NICO for patients

A patient information sheet is included in the package of NICOTROL Inhaler cartridges dispensed to the patient. Patients should be encouraged to read the information sheet carefully and to ask their physician and pharmacist about the proper use of the product .

Patients must be advised to keep both used and unused cartridges out of the reach of children and pets.

NICO Interactions

Physiological changes resulting from smoking cessation, with or without nicotine replacement, may alter the pharmacokinetics of certain concomitant medications, such as tricyclic antidepressants and theophylline. Doses of these and perhaps other medications may need to be adjusted in patients who successfully quit smoking.

NICO Contraindications

Use of NICOTROL Inhaler therapy is contraindicated in patients with known hypersensitivity or allergy to nicotine or to menthol.

Manufacturers name:

  • Avion Pharmaceuticals, LLC

Generic name, Overdose, Half Life NICO, Food Interactions, Chemical, etc..

NICO see also FDA report

Chemical structure:
N N H H H H H H H H H H H H H H C10H14N2 2D chemical structure C10H14N2 SVG | 2D structure Nicotine chemical names, chemical properties, classification C10H14N2