Navelbine

Navelbine (Navelbine®) is an anti-mitotic chemotherapy drug that is given as a treatment for some types of cancer, including breast cancer and non-small cell lung cancer. .
[Wikipedia].

Navelbine - Pharmacology:

The antitumor activity of vinorelbine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Like other vinca alkaloids, vinorelbine may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin-dependent Ca2+-transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis.

Navelbine mini report

Navelbine NDA
NDA - A product marketed under an approved New Drug Application
Navelbine INTRAVENOUS
INTRAVENOUS
Navelbine HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Navelbine global name
Vinorelbine tartrate
Start - Stop data
START DATA:
2005-Nov-15
Start - Stop data
STOP DATA
not occurred

Navelbine Interactions

Acute pulmonary reactions have been reported with NAVELBINE and other anticancer vinca alkaloids used in conjunction with mitomycin. Although the pharmacokinetics of vinorelbine are not influenced by the concurrent administration of cisplatin, the incidence of granulocytopenia with NAVELBINE used in combination with cisplatin is significantly higher than with single-agent NAVELBINE. Patients who receive NAVELBINE and paclitaxel, either concomitantly or sequentially, should be monitored for signs and symptoms of neuropathy. Administration of NAVELBINE to patients with prior or concomitant radiation therapy may result in radiosensitizing effects.

Caution should be exercised in patients concurrently taking drugs known to inhibit drug metabolism by hepatic cytochrome P450 isoenzymes in the CYP3A subfamily, or in patients with hepatic dysfunction. Concurrent administration of vinorelbine tartrate with an inhibitor of this metabolic pathway may cause an earlier onset and/or an increased severity of side effects.

 

Navelbine Contraindications

Administration of NAVELBINE is contraindicated in patients with pretreatment granulocyte counts <1,000 cells/mm3.

Generic name, Overdose, Half Life Navelbine, Food Interactions, Chemical, etc..

Navelbine see also FDA report


Chemical structure:
N N N N O O O O O O O O H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H C45H54N4O8 2D chemical structure C45H54N4O8 SVG | 2D structure chemical names, chemical properties, classification C45H54N4O8