Normix is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It is used to treat diarrhea caused by E. coli.

Normix - Pharmacology:

Normix is a product of synthesis of rifamycin, an antibiotic with low gastrointestinal absorption and good antibacterial activity (Marchi et al, 1985). It acts on the beta-subunit of the deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase enzyme of microorganisms to inhibit RNA synthesis.

Normix for patients

Patients should be advised that XIFAXAN™ Tablets may be taken with or without food. Patients should be advised that XIFAXAN™ Tablets should be discontinued if their diarrhea persists more than 24-48 hours or worsens, or if they have fever and/or blood in the stool that they should seek medical care.

Normix Interactions

Drug-Drug Interactions

Although in vitro studies demonstrated the potential of rifaximin to interact with cytochrome P450 3A4 (CYP3A4), a clinical drug-drug interaction study demonstrated that rifaximin did not significantly affect the pharmacokinetics of midazolam either presystemically or systemically. An additional clinical drug-drug interaction study showed no effect of rifaximin on the presystemic metabolism of an oral contraceptive containing ethinyl estradiol and norgestimate. Therefore, clinical interactions with drugs metabolized by human cytochrome P450 isoenzymes are not expected.


Normix Contraindications

XIFAXAN™ Tablets are contraindicated in patients with a hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN™ Tablets.

Normix tags categories:

Generic name, Overdose, Half Life Normix, Food Interactions, Chemical, etc..

Normix see also

Brand Names containing Rifaximin

Chemical structure:
O O O O O O H O O O O O N N N H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H C43H51N3O11 2D chemical structure C43H51N3O11 SVG | 2D structure chemical names, chemical properties, classification C43H51N3O11