A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). .

Novocaine - Pharmacology:

Novocaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Novocaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.

Novocaine Interactions


Concurrent use of procaine hydrochloride and anticholinesterase agents may result in increased systemic toxicity since anticholinesterases inhibit the breakdown of procaine hydrochloride.


Concurrent use of procaine hydrochloride and antimyasthenics may result in loss of control of symptoms of myasthenia gravis due to antagonism of the effects of antimyasthenics on skeletal muscle. Temporary dosage adjustment of antimyasthenics may be required. Also antimyasthenics may have anticholinesterase activity.

CNS depressant medications

Concurrent use of procaine hydrochloride and CNS depressant medications may result in additive depressant effects.


Hyaluronidase may increase the diffusion rate of procaine hydrochloride, resulting in a decreased time of onset, but an increase in systemic toxicity.

Neuromuscular blocking agents (such as suxamethonium chloride)

Concurrent use of procaine hydrochloride and neuromuscular blocking agents may result in prolongation or enhancement of the neuromuscular blockade.


Concurrent use of procaine hydrochloride and sulfonamides may result in a reduction of the antibacterial action of the sulfonamide.


Concurrent use of acetazolamide and procaine hydrochloride may extend the plasma half-life of procaine.

Generic name, Overdose, Half Life Novocaine, Food Interactions, Chemical, etc..

Novocaine see also

Chemical structure:
O N O N H H H H H H H H H H H H H H H H H H H H C13H20N2O2 2D chemical structure C13H20N2O2 SVG | 2D structure Procaine chemical names, chemical properties, classification C13H20N2O2