Antitumor alkaloid isolated from Vinca Rosea. (Merck, 11th ed.)

Oncovin - Pharmacology:

The antitumor activity of Oncovin is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Like other vinca alkaloids, Oncovin may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin-dependent Ca2+-transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis.

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Oncovin Interactions

The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included vincristine sulfate has been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. Dosage adjustment should be based on serial blood level monitoring. The contribution of vincristine sulfate to this interaction is not certain. The interaction may result from reduced absorption of phenytoin and an increase in the rate of its metabolism and elimination.

Oncovin Contraindications

Patients with the demyelinating form of Charcot-Marie-Tooth syndrome would not be given vincristine sulfate injection.

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Brand Names containing Vincristine

Chemical structure:
N N N + N O _ O O O O O O O O O H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H C46H56N4O10 2D chemical structure C46H56N4O10 SVG | 2D structure chemical names, chemical properties, classification C46H56N4O10