PBZ

A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. PBZ is administered by various routes, including topically. .
[PubChem].

PBZ - Pharmacology:

PBZ binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

PBZ for patients

Take with food, water, or milk to minimize gastric irritation. Swallow the extended-release dosage form whole (do not crush). If you miss a dose, take as soon as possible but do not take if it is almost time for your next dose. DO NOT double up on doses. Notify your doctor if skin tests using allergens is required as this medication may interfere with test results. Avoid use of alcohol or other CNS depressants while taking this medication. This medication can cause drowsiness or dizziness. Use caution while taking this medicine when driving or using equipment. Talk to your doctor if you are taking appetite suppressants. This medication can cause insomnia. Take the medication a few hours before bedtime if this occurs. This medication can cause dryness of mouth - use sugarless gum, candy, ice, or saliva substitute for relief. Check with your dentist if dry mouth continues for more than 2 weeks.

PBZ Interactions

PBZ can interact with alcohol or other CNS depressants (may potentiate the CNS depressant effects of either these medications or antihistamines), anticholinergics or other medications with anticholinergic activity (anticholinergic effects may be potentiated when these medications are used concurrently with antihistamines), and monoamine oxidase (MAO) inhibitors (concurrent use with antihistamines may prolong and intensify the anticholinergic and CNS depressant effects of antihistamines).

PBZ Contraindications

Contraindicated in the following: blood disease, heart or blood vessel disease (may cause more serious conditions to develop), enlarged prostate, urinary tract blockage or difficult urination (phenothiazine-derivative antihistamines may cause urinary problems to become worse), epilepsy (phenothiazine-derivative antihistamines, especially promethazine given by injection, may increase the chance of seizures), glaucoma (may cause a slight increase in inner eye pressure that may worsen the condition, jaundice (phenothiazine-derivative antihistamines may make the condition worse), liver disease (phenothiazine-derivative antihistamines may build up in the body, which may increase the chance of side effects such as muscle spasms), Reyes syndrome (phenothiazine-derivative antihistamines, especially promethazine given by injection, may increase the chance of uncontrolled movements).

Generic name, Overdose, Half Life PBZ, Food Interactions, Chemical, etc..

PBZ see also


Chemical structure:
N N N H H H H H H H H H H H H H H H H H H H H H C16H21N3 2D chemical structure C16H21N3 SVG | 2D structure Tripelennamine chemical names, chemical properties, classification C16H21N3