Paser

An antitubercular agent often administered in association with isoniazid. The sodium salt of the drug is better tolerated than the free acid. .
[PubChem].

Paser - Pharmacology:

There are two mechanisms responsible for aminosalicylic acid's bacteriostatic action against Mycobacterium tuberculosis. Firstly, aminosalicylic acid inhibits folic acid synthesis (without potentiation with antifolic compounds). The binding of para-aminobenzoic acid to pteridine synthetase acts as the first step in folic acid synthesis. Aminosalicylic acid binds pteridine synthetase with greater affinity than para-aminobenzoic acid, effectively inhibiting the synthesis of folic acid. As bacteria are unable to use external sources of folic acid, cell growth and multiplication slows. Secondly, aminosalicylic acid may inhibit the synthesis of the cell wall component, mycobactin, thus reducing iron uptake by M. tuberculosis.

Paser mini report

Paser ANDA
ANDA - A product marketed under an approved Abbreviated New Drug Application
Paser GRANULE, DELAYED RELEASE
GRANULE, DELAYED RELEASE
Paser HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Paser global name
AMINOSALICYLIC ACID
Start - Stop data
START DATA:
1995-Feb-15
Start - Stop data
STOP DATA
not occurred

Paser for patients

Take all of the aminosalicylic acid that has been prescribed for you even if you start to feel better. Your symptoms may begin to improve before the infection is completely treated, and stopping the medicine before the infection has been completely treated may lead to bacterial resistance. Do not take this medicine if it is brown or purple in color or if the package has swollen. This appearance means that the drug has lost its effectiveness. Aminosalicylic acid will turn brown or purple if left in a hot place, if it is kept in direct sunlight, or if it is exposed to water or moisture. Call your doctor immediately if you experience a fever, a sore throat, unusual bleeding or bruising, or a skin rash.

Paser Interactions

Aminosalicylic acid may decrease the amount of digoxin (Lanoxin, Lanoxicaps) that gets absorbed into your body. In the case that you are taking digoxin while taking aminosalicylic acid, higher doses of digoxin may be needed. Aminosalicylic acid may also decrease the absorption of vitamin B12, which can lead to a deficiency. Therefore you may need to take a vitamin B12 supplement while taking aminosalicylic acid.

Paser Contraindications

Patients with hypersensitivity to any component of this medication should not receive aminosalicylic acid. Patients with severe renal disease will accumulate aminosalicylic acid and its acetyl metabolite but will continue to acetylate, thus leading exclusively to the inactive acetylated form; deacetylation, if any, is not significant. In addition, patients with end stage renal disease should not receive aminosalicylic acid.

Generic name, Overdose, Half Life Paser, Food Interactions, Chemical, etc..

Paser see also FDA report

Brand Names containing Aminosalicylic Acid

Chemical structure:
O + N _ O O H H H H H H H C7H7NO3 2D chemical structure C7H7NO3 SVG | 2D structure Aminosalicylic Acid | Mesalazine | 3-Hydroxyanthranilic Acid | Salicylhydroxamic Acid | 2-Nitro-P-Cresol | Trencam-3,2-Hopo | chemical names, chemical properties, classification C7H7NO3