Plavix

Plavix, an antiplatelet agent structurally and pharmacologically similar to ticlopidine, is used to reduce atherosclerotic events such as myocardial infarction, stroke, and vascular death in patients who have had a recent stroke, recent MI, or have established peripheral vascular disease.

Plavix - Pharmacology:

The active metabolite of clopidogrel prevents binding of adenosine diphosphate (ADP) to its platelet receptor, impairing the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. It is proposed that the inhibition involves a defect in the mobilization from the storage sites of the platelet granules to the outer membrane. No direct interference occurs with the GPIIb/IIIa receptor. As the glycoprotein GPIIb/IIIa complex is the major receptor for fibrinogen, its impaired activation prevents fibrinogen binding to platelets and inhibits platelet aggregation. By blocking the amplification of platelet activation by released ADP, platelet aggregation induced by agonists other than ADP is also inhibited by the active metabolite of clopidogrel.

Plavix mini report

Plavix NDA
NDA - A product marketed under an approved New Drug Application
Plavix TABLET, FILM COATED
TABLET, FILM COATED
Plavix HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Plavix global name
CLOPIDOGREL BISULFATE
Plavix global name
clopidogrel bisulfate
Start - Stop data
START DATA:
1900-Jan-01
Start - Stop data
STOP DATA
not occurred

Medicinal name:

  • Clopidogrel 75 MG Oral Tablet
  • Clopidogrel 300 MG Oral Tablet

Plavix for patients

Patients should be told that they may bleed more easily and it may take them longer than usual to stop bleeding when they take Plavix or Plavix combined with aspirin, and that they should report any unusual bleeding to their physician. Patients should inform physicians and dentists that they are taking Plavix and/or any other product known to affect bleeding before any surgery is scheduled and before any new drug is taken.

Plavix Interactions

Aspirin, warfarin, heparin, NSAIDs

Plavix Contraindications

The use of Plavix is contraindicated in the following conditions:

· Hypersensitivity to the drug substance or any component of the product.
· Active pathological bleeding such as peptic ulcer or intracranial hemorrhage.

Trusted Medical Info

Known as the Merck-KGaA manual in the US & Canada and as the MSD manual in the rest of the World

Manufacturers name:

  • PD-Rx Pharmaceuticals, Inc
  • State of Florida DOH Central Pharmacy
  • REMEDYREPACK INC
  • Cardinal Health
  • Physicians Total Care, Inc
  • Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC
  • STAT RX USA LLC
  • A-S Medication Solutions LLC
  • Rebel Distributors Corp
  • Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership
  • Contract Pharmacy Services-PA
  • Bryant Ranch Prepack

Generic name, Overdose, Half Life Plavix, Food Interactions, Chemical, etc..

Plavix see also


Chemical structure:
O N O Cl S H H H H H H H H H H H H H H H H C16H16ClNO2S 2D chemical structure C16H16ClNO2S SVG | 2D structure Clopidogrel chemical names, chemical properties, classification C16H16ClNO2S

Picture Plavix