Prilosec

A highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and zollinger-ellison syndrome. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-exchanging ATPase) in the proton pump of gastric parietal cells. .
[PubChem].

Medicinal name:
  • Omeprazole 40 MG Delayed Release Oral Capsule [Prilosec]
  • Omeprazole 20 MG Delayed Release Oral Tablet [Prilosec]
  • Omeprazole 20 MG Delayed Release Oral Capsule [Prilosec]
  • Omeprazole 10 MG Delayed Release Oral Capsule [Prilosec]

Prilosec - Pharmacology:

Prilosec is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, omeprazole blocks the final step in acid production, thus reducing gastric acidity.

Prilosec mini report

Prilosec NDA
NDA - A product marketed under an approved New Drug Application
Prilosec CAPSULE
CAPSULE
Prilosec CAPSULE, DELAYED RELEASE
CAPSULE, DELAYED RELEASE
Prilosec GRANULE, DELAYED RELEASE
GRANULE, DELAYED RELEASE
Prilosec HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Prilosec global name
OMEPRAZOLE MAGNESIUM
Prilosec global name
Omeprazole magnesium
Start - Stop data
START DATA:
2009-Sep-30
Start - Stop data
STOP DATA
not occurred

Prilosec for patients

PRILOSEC Delayed-Release Capsules should be taken before eating. Patients should be cautioned that the PRILOSEC Delayed-Release Capsule should not be opened, chewed or crushed, and should be swallowed whole.

For patients who have difficulty swallowing capsules, the contents of a PRILOSEC Delayed-Release Capsule can be added to applesauce. One tablespoon of applesauce should be added to an empty bowl and the capsule should be opened. All of the pellets inside the capsule should be carefully emptied on the applesauce. The pellets should be mixed with the applesauce and then swallowed immediately with a glass of cool water to ensure complete swallowing of the pellets. The applesauce used should not be hot and should be soft enough to be swallowed without chewing. The pellets should not be chewed or crushed. The pellets/applesauce mixture should not be stored for future use.

Prilosec Interactions

Other

Prilosec can prolong the elimination of diazepam, warfarin and phenytoin, drugs that are metabolized by oxidation in the liver. Although in normal subjects no interaction with theophylline or propranolol was found, there have been clinical reports of interaction with other drugs metabolized via the cytochrome P-450 system (e.g., cyclosporine, disulfiram, benzodiazepines). Patients should be monitored to determine if it is necessary to adjust the dosage of these drugs when taken concomitantly with omeprazole.

Because of its profound and long lasting inhibition of gastric acid secretion, it is theoretically possible that omeprazole may interfere with absorption of drugs where gastric pH is an important determinant of their bioavailability (e.g., ketoconazole, ampicillin esters, and iron salts). In the clinical trials, antacids were used concomitantly with the administration of omeprazole.

Combination Therapy with Clarithromycin

Co-administration of omeprazole and clarithromycin may result in increases in plasma levels of ompeprazole, clarithromycin, and 14-hydroxy-clarithromycin.

Concomitant administration of clarithromycin with cisapride, pimozide, or terfenadine is contraindicated.

There have been reports of an intereaction between erythromycin and astemizole resulting in QT prolongation and torsades de points. Concomitant administration of erythromycin and astemizole is contraindicated. Because clarithromycin is also metabolized by cytochrome P450, concomitant administration of clarithromycin with astemizole is not recommended.

Prilosec Contraindications

Prilosec

Prilosec delayed-release capsules are contraindicated in patients with known hypersensitivity to any component of the formulation.

Manufacturers name:

  • AstraZeneca LP
  • Physicians Total Care, Inc
  • Procter & Gamble Manufacturing Company
  • STAT RX USA LLC

Generic name, Overdose, Half Life Prilosec, Food Interactions, Chemical, etc..

Prilosec see also FDA report Saw Palmetto

Gastro Health

Chemical structure:
N O S O O N N H H H H H H H H H H H H H H H H H H H C17H19N3O3S 2D chemical structure C17H19N3O3S SVG | 2D structure Omeprazole | Esomeprazole | chemical names, chemical properties, classification C17H19N3O3S