Prinivil Indication:

For the treatment of hypertension, heart failure and acute myocardial infarction. It may be used alone or in combination with thiazide diuretics

Prinivil Mechanism Of Action:

Prinivil competes with angiotensin I for its binding site on the angiotensin-converting enzyme (ACE), an enzyme which converts angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative feedback mediator for renin activity, lower angiotensin II plasma levels result in decreased blood pressure and increased plasma renin activity. Baroreceptor reflex mechanisms, stimulated by the fall in blood pressure, release kininase II, an enzyme identical to ACE that degrades bradykinin, a vasodilator.

Prinivil Drug Interactions:

Amiloride Increased risk of hyperkaliemia
Triamterene Increased risk of hyperkaliemia
Spironolactone Increased risk of hyperkaliemia
Potassium Increased risk of hyperkaliemia
Drospirenone Increased risk of hyperkaliemia
Clozapine Increases the effect and toxicity of clozapine
Lithium The ACE inhibitor increases serum levels of lithium
Tizanidine Tizanidine increases the risk of hypotension with the ACE inhibitor

Prinivil Food Interactions:

Avoid alcohol.
Avoid excess salt/sodium unless otherwise instructed by your physician.
Avoid salt substitutes containing potassium.
Avoid natural licorice.
Take without regard to meals.

Prinivil Generic Name:

Synonyms:

  • Not Available

Drug Type:

Small Molecule; Approved

Absorption:

Approximately 25%, but widely variable between individuals (6 to 60%)

Toxicity (Overdose):

hypotension, LD50= 2000 mg/kg(orally in rat)

Protein Binding:

Lisinopril does not appear to be bound to other serum proteins

Biotransformation:

Lisinopril does not undergo metabolism and is excreted unchanged entirely in the urine

Half Life:

12 hours

Dosage Forms of Prinivil:

Tablet Oral

Chemical IUPAC Name:

(2S)-1-[(2S)-6-amino-2-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]hexanoyl]pyrrolidine-2-carboxylic acid

Organisms Affected:

Humans and other mammals

Prinivil to general, pharmacology

General, pharmacology..