Provera Indication:

For progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency and for the treatment of secondary amenorrhea. Also used as a female contraceptive.

Provera Mechanism Of Action:

Binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Provera will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.

Provera Drug Interactions:

Not Available

Provera Food Interactions:

Avoid alcohol.
Take with food.
Avoid excessive quantities of coffee or tea (Caffeine).
Increase dietary intake of magnesium, folate, vitamin B6, B12, and/or consider taking a multivitamin.
Take at the same time everyday.

Provera Generic Name:


  • Progesterona [Inn-Spanish]
  • Progesteronum
  • Progesteronum [Inn-Latin]
  • Corpus Luteum Hormone

Drug Type:

Small Molecule; Approved


Progesterone absorption is prolonged with an absorption half-life of approximately 25-50 hours.

Toxicity (Overdose):

Not Available

Protein Binding:



Progesterone is metabolized primarily by the liver largely to pregnanediols and pregnanolones.

Half Life:

34.8-55.13 hours

Dosage Forms of Provera:

Gel Intravaginal
Capsule Oral
Liquid Intramuscular

Chemical IUPAC Name:


Organisms Affected:

Humans and other mammals

Provera to general, pharmacology

General, pharmacology..
Women's Health