Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.

Medicinal name:
  • Ranitidine 150 MG Oral Tablet
  • Ranitidine 75 MG Oral Tablet
  • Ranitidine 300 MG Oral Tablet
  • Ranitidine 150 MG Oral Capsule
  • Ranitidine 300 MG Oral Capsule
  • 12 HR ranolazine 500 MG Extended Release Oral Tablet [Ranexa]
  • 12 HR ranolazine 1000 MG Extended Release Oral Tablet [Ranexa]

RAN - Pharmacology:

RAN stimulates erythropoiesis by the same mechanism as endogenous erythropoietin. Erythropoietin interacts with
progenitor stem cells to increase red cell production. Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization, which facilitates activation of JAK-STAT signaling pathways within the cytosol. Activated STAT (signal transducers and activators of transcription) proteins are then translocated to the nucleus where they serve as transcription factors which regulate the activation of specific genes involved in cell division or differentiation.

RAN for patients

Patients should be informed of the possible side effects of Aranesp® and be instructed to report them to the prescribing physician. Patients should be informed of the signs and symptoms of allergic drug reactions and be advised of appropriate actions. Patients should be counseled on the importance of compliance with their Aranesp® treatment, dietary and dialysis prescriptions, and the importance of judicious monitoring of blood pressure and hemoglobin concentration should be stressed.

It is recommended that Aranesp® should be administered by a healthcare professional. In those rare cases where it is determined that a patient can safely and effectively administer Aranesp® at home, appropriate instruction on the proper use of Aranesp® should be provided for patients and their caregivers, including careful review of the accompanying "Information for Patients" insert. Patients and caregivers should also be cautioned against the reuse of needles, syringes, or drug product, and be thoroughly instructed in their proper disposal. A puncture-resistant container for the disposal of used syringes and needles should be made available to the patient.

RAN Interactions

No formal drug interaction studies of Aranesp® have been performed.

RAN Contraindications

Aranesp® is contraindicated in patients with:

• uncontrolled hypertension

• known hypersensitivity to the active substance or any of the excipients

Manufacturers name:

  • IVAX Pharmaceuticals, Inc
  • Premier Value
  • Blenheim Pharmacal, Inc
  • Glenmark Generics Inc, USA
  • PD-Rx Pharmaceuticals, Inc
  • State of Florida DOH Central Pharmacy
  • Mylan Institutional Inc
  • Select Brand
  • Sandoz Inc
  • Sunmark
  • Rebel Distributors Corp
  • Unit Dose Services
  • NCS HealthCare of KY, Inc dba Vangard Labs
  • AvKARE, Inc
  • Contract Pharmacy Services-PA
  • Dr Reddys Laboratories Limited
  • Carilion Materials Management
  • Cardinal Health
  • Amneal Pharmaceuticals
  • Bryant Ranch Prepack
  • MedVantx, Inc
  • Lake Erie Medical DBA Quality Care Products LLC
  • St Marys Medical Park Pharmacy
  • Gilead Sciences, Inc
  • American Health Packaging
  • McKesson Packaging Services Business Unit of McKesson Corporation
  • RxChange Co
  • Proficient Rx LP
  • Northwind Pharmaceuticals, LLC
  • Preferred Pharmaceuticals, Inc
  • Liberty Pharmaceuticals, Inc
  • Physicians Total Care, Inc
  • Target Brands Inc
  • Aidarex Pharmaceuticals LLC
  • Rebel Distributors
  • Apotex Corp
  • CVS Pharmacy, Inc
  • Par Pharmaceutical Inc
  • Direct Rx
  • McKesson Contract Packaging
  • Watson Laboratories, Inc
  • Freds Inc
  • Clinical Solutions Wholesale
  • Keltman Pharmaceuticals Inc
  • Shopko Stores Operating Co, LLC
  • Walmart Stores Inc
  • P and L Development of New York Corporation
  • Walgreen Company
  • Amerisource Bergen
  • Major Pharmaceuticals
  • Wal-Mart Stores, Inc
  • Chain Drug Marketing Association Inc
  • Valu Merchandisers Company
  • Medline Industries, Inc
  • Health Mart
  • Shasun Pharmaceuticals Limited
  • HyVee Inc

Generic name, Overdose, Half Life RAN, Food Interactions, Chemical, etc..

RAN see also

Brand Names containing Darbepoetin alfa