Reglan

A dopamine D2 antagonist that is used as an antiemetic. .
[PubChem].

Medicinal name:
  • Metoclopramide 10 MG Oral Tablet [Reglan]
  • Metoclopramide 5 MG Oral Tablet [Reglan]

Reglan - Pharmacology:

Reglan inhibits gastric smooth muscle relaxation produced by dopamine, therefore increasing cholinergic response of the gastrointestinal smooth muscle. It accelerates intestinal transit and gastric emptying by preventing relaxation of gastric body and increasing the phasic activity of antrum. Simultaneously, this action is accompanied by relaxation of the upper small intestine, resulting in an improved coordination between the body and antrum of the stomach and the upper small intestine. Reglan also decreases reflux into the esophagus by increasing the resting pressure of the lower esophageal sphincter and improves acid clearance from the esophagus by increasing amplitude of esophageal peristaltic contractions. Reglan's dopamine antagonist action raises the threshold of activity in the chemoreceptor trigger zone and decreases the input from afferent visceral nerves. Studies have also shown that high doses of metoclopramide can antagonize 5-hydroxytryptamine (5-HT) receptors in the peripheral nervous system in animals.

Reglan mini report

Reglan NDA
NDA - A product marketed under an approved New Drug Application
Reglan INTRAMUSCULAR; INTRAVENOUS
INTRAMUSCULAR; INTRAVENOUS
Reglan ORAL
ORAL
Reglan INJECTION, SOLUTION
INJECTION, SOLUTION
Reglan TABLET
TABLET
Reglan HUMAN PRESCRIPTION DRUG
HUMAN PRESCRIPTION DRUG
Reglan global name
Metoclopramide Hydrochloride
Reglan global name
METOCLOPRAMIDE HYDROCHLORIDE
Start - Stop data
START DATA:
2010-Aug-01
Start - Stop data
STOP DATA
not occurred

Reglan for patients

Reglan may impair the mental and/or physical abilities required for the performance of hazardous tasks such as operating machinery or driving a motor vehicle.The ambulatory patient should be cautioned accordingly.

Reglan Interactions

The effects of metoclopramide on gastrointestinal motility are antagonized by anticholinergic drugs and narcotic analgesics. Additive sedative effects can occur when metoclopramide is given with alcohol, sedatives, hypnotics, narcotics, or tranquilizers.

The finding that metoclopramide releases catecholamines in patients with essential hypertension suggests that it should be used cautiously, if at all, in patients receiving monoamine oxi-dase inhibitors.

Absorption of drugs from the stomach may be diminished (e.g., digoxin) by metoclopramide, whereas the rate and/or extent of absorption of drugs from the small bowel may be increased (e.g., acetaminophen, tetracycline, levodopa, ethanol, cyclosporine).

Gastroparesis (gastric stasis) may be responsible for poor diabetic control in some patients. Exogenously administered insulin may begin to act before food has left the stomach and lead to hypoglycemia. Because the action of metoclopramide will influence the delivery of food to the intestines and thus the rate of absorption, insulin dosage or timing of dosage may require adjustment.

Reglan Contraindications

Reglan should not be used whenever stimulation of gastrointestinal motility might be dangerous, e.g., in the presence of gastrointestinal hemorrhage, mechanical obstruction, or perforation.

Reglan is contraindicated in patients with pheochro-mocytoma because the drug may cause a hypertensive crisis, probably due to release of catecholamines from the tumor. Such hypertensive crises may be controlled by phen-tolamine.

Reglan is contraindicated in patients with known sensitivity or intolerance to the drug.

Reglan should not be used in epileptics or patients receiving other drugs which are likely to cause extrapyramidal reactions, since the frequency and severity of seizures or extrapyramidal reactions may be increased.

Manufacturers name:

  • ANI Pharmaceuticals, Inc
  • UCB, Inc
  • STAT RX USA LLC

Reglan tags categories:

Generic name, Overdose, Half Life Reglan, Food Interactions, Chemical, etc..

Reglan see also FDA report Saw Palmetto

Gastro Health

Chemical structure:
N N Cl O O N H H H H H H H H H H H H H H H H H H H H H H C14H22ClN3O2 2D chemical structure C14H22ClN3O2 SVG | 2D structure Metoclopramide chemical names, chemical properties, classification C14H22ClN3O2